Award Data

The goal of this NIH Phase I SBIR proposal is to develop and validate a new method to monitor the symptomatic toxicities and health related quality of life of cancer patients who are undergoing and have undergone radiation therapy during the course of their treatmentThe proposal is built around expertise in mobile application developmentVivonics Incand radiation oncologyDrTJ Fitzgerald of the Univ ...

This project develops and tests two novel functional gel compositions to be used with intermittent and indwelling catheters. There is a high incidence of life-long recurrent urinary tract infection (UTI) in individuals with neuro-urologic disorders who use these catheters due to continuous, repeated catheterization, and compromises in the hygiene and the natural mucosal barrier. This results in ch ...

The goal of the project is to develop a device for percutaneous closure of postinfarction ventricular septal defectVSDin adultsFirst a prototype would be developed and tested in animalsand ultimately a clinical grade device would undergo regulatory developmentPhase I will include the development and testing of a postinfarction VSD occluder prototypePhase II will include mechanical and safety testi ...

Needle access to deep organs is common to numerous catheterradiologicaland surgical proceduresboth diagnostic and therapeuticincluding access to blood vesselspericardial and cardiac chambersvisceraetcMRI operation affords exquisite imaging and delineation of soft tissue beyond what is afforded by X ray fluoroscopyCTand ultrasound guidancePassiveneedles visualized solely by their material propertie ...

The goal of Phase I is to develop and test a Transcatheter Potts Shunt prototype system in vivoThe deliverable is a catheter system to establish a non surgical Potts Shunttranscatheter pulmonary to aortic anastomosisto treat refractory pulmonary artery hypertensionPhase I will focus on mechanical and biological performance of the proposed endografttaking into account mechanical strength required f ...

HIVthe virus that causes AIDSis one of the world s most serious health challengesAccording to UNAIDSthere were approximatelymillion people worldwide living with HIV AIDS at the end ofThe vast majority of them are in lowto middle income countriesparticularly in sub Saharan AfricaA low cost vaccine broadly neutralizing most strains of HIV is the preferred response to protect the human populationHowe ...

The wide availability of rapidfield portablelow costand sensitive molecular diagnostic for point of care detection of malaria parasites would have a significant benefit for intervention programs aimed at eliminating malaria in affected populationsMalaria remains one of the most serious infectious diseases in low income countriesthreatening nearly half of the world s population and causing an estim ...

Bronchial asthma is a chronic respiratory disease that can be lethalAsthma is a global health problemAccording to the CDCin USAthere are currentlymillion asthma sufferers and this number is increasingHalf of the asthma patients have at least one hospitalization per yearwith an annual medical cost of $BTraditionallyasthma is treated during flare ups with prescribed inhaled corticosteriodsIn recent ...

The goal of this project is to fabricate a novel nanoscintillator photosensitizer complex for X ray excited photodynamic therapyXPDTHereina low dose of X raysltGyis used to excite scintillating nanoparticleswhich downconvert ionizing radiation to UV vis lightPhotosensitizers loaded onto the nanoscintillator complex absorb this UV vis emission and generate cytotoxic reactive oxygen speciesROSin the ...

The overall objective of this Phase I SBIR project is to study the feasibility and acceptability of SurvivorCarea mobileand web based system to support long term cancer survivorship through patient navigation for low incomeunderserved populationsFollowing a user centered design approachthe contractor will develop a tool expressly designed for patient navigatorsPNsand colorectal cancer survivors to ...