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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Bullet Proof vascular graft to prevent dialysis access cannulation injury

    SBC: Innavasc Medical, Inc.            Topic: 400

    Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Accelerated discovery of methylation targeted therapeutic development

    SBC: Epicypher, Inc.            Topic: 102

    Project Summary Nucleosomes are the fundamental and repeating units of chromatin consisting of DNA wrapped around a histone octamer Alterations in chromatin structure and function dramatically impact downstream gene expression and cellular physiology This epigenetic regulation is controlled by two major modifications histone post translational modifications PTMs such as histone methylation ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Acoustic lysis and extraction system for limited cell number applications

    SBC: COVARIS, INC.            Topic: 200

    DESCRIPTION provided by applicant Analysis of single cells or cells that are not present in large numbers in the body is important to understanding basic biology and diseases A specific example is cancer in which changes in DNA in a single cell can lead to that cell reproducing rapidly Similarly studying the proteins that make up these cells can tell us how the changes in DNA result in ch ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Acute Pancreatitis: Renalase as a novel target and agonists as new therapy

    SBC: BESSOR PHARMA, LLC            Topic: 300

    Project Summary Abstract This proposal brings together a top team with diverse and complementary expertise to develop a novel therapeutic agent based on a newly described serum protein renalase RNLS to treat acute pancreatitis AP This protein appears to have a novel protective effect in models of acute tissue injury including AP AP affects more than people year in the USA and can c ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. A HOMOGENEOUS ASSAY FOR HEPATITIS B VIRUS SURFACE ANTIGEN

    SBC: Liposome Sciences Inc.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  6. A Library of Immunoaffinity Reagents for RNA modifications

    SBC: VISTERRA, INC.            Topic: NIDA

    Project Abstract While there are commercial monoclonal antibodies against several RNA modifications there is a general paucity of immunological tools for the andgt known RNA modifications This lack of immunological tools is hindering study of the emerging roles for modified ribonucleosides as critical players in the many basic cell and organismal processes in viruses bacteria parasites and ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A LONG-RANGE AIM OF THIS PROPOSED WORK IS TO DEVELOP A CLINICAL TEST BASED ON PATTERNS OF NEUROTRANSMITTERS (MONOAMINES, PEPTIDES/PRECURSORS, METABOLITES, AND CONJUGATES) WHICH CAN BE USED TO GUIDE AND DEVELOP THERAPY AND PREDICT OUTCOME IN PATIENTS WITH

    SBC: ESA, INC.            Topic: N/A

    A LONG-RANGE AIM OF THIS PROPOSED WORK IS TO DEVELOP A CLINICAL TEST BASED ON PATTERNS OF NEUROTRANSMITTERS (MONOAMINES, PEPTIDES/PRECURSORS, METABOLITES, AND CONJUGATES) WHICH CAN BE USED TO GUIDE AND DEVELOP THERAPY AND PREDICT OUTCOME IN PATIENTS WITH TRIGEMINAL NEURALGIA (TGM) AND OTHER FORMS OF FACIAL PAIN. NEW TECHNOLOGY INTERFACING UP TO 32 MULTIPLE ELECTRODE SENSORS WITH LIQUID CHROMATOGRA ...

    SBIR Phase I 1985 Department of Health and Human Services
  8. ANALYSIS OF YEAST GLYCOSYLATION OF A HUMAN GLYCOPROTEIN

    SBC: C-MOTION, INC.            Topic: N/A

    N/A

    SBIR Phase I 1985 Department of Health and Human Services
  9. An Automated Device for High Yield Mesenchymal Stem Cell Extraction

    SBC: CG SCIENTIFIC INC            Topic: 100

    DESCRIPTION provided by applicant This project aims to develop an automated device for extracting mesenchymal stem cells MSCs in clinically relevant quantities from adipose tissues for treating many serious diseases including myocardial infarction diabetes liver cirrhosis and graft versus host disease Over clinical trials to date have established the feasibility safet and in some c ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE.

    SBC: H. G. Pars Pharmaceutical Labo            Topic: N/A

    AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE. GOSSYPOL, THE MOST PROMISING NONSTEROIDAL MALE ANTIFERTILITY LEAD, HAS AN UNACCEPTABLY NARROW THERAPEUTIC RATIO. WE PROPOSE THAT THE THERAPEUTIC RATIO MAY BE IMPROVED BY ALTERATION OF THE PHARMACOKINETICS AND BIOAVAILABILITY THROUGH WATER-SOLUBILIZATION. ACCORDINGLY, SEVERAL CAREFULLY CHO ...

    SBIR Phase I 1985 Department of Health and Human Services
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