Award Data

A. WE PROPOSE TO DEVELOP A METHODOLOGY BY WHICH THE GENES CODING FOR DISEASE-SPECIFIC ANTIGENS CAN BE RAPIDLY CLONED USING RECOMBINANT DNA TECHNIQUES. THE SYSTEM LENDS ITSELF TO HIGH LEVEL EXPRESSION OF THESE ANTIGENS AS HYBRID PROTEINS, WHICH FACILITATES PRODUCTION OF ANTIBODIES TO THE ANTIGENS. WITH BOTH ANTIGEN AND ANTIBODY, IMMUNODIAGNOSTIC TESTS CAN BE PRODUCED FOR DETECTION OF THESE ANTIGENS ...

Diode-laser arrays operating in the visible region of the spectrum offer advantages for illuminator applications, particularly for night and water penetration capability. Recent developments in diode-laser materials allow operation throughout the visiblespectrum. At this time, red diode-laser technology is more mature than the existing blue-green or violet diode-laser technology. The novel aspe ...

DESCRIPTION (provided by applicant): The current Phase I SBIR Grant application by Inotek Pharmaceuticals Corporation proposes to test the antinociceptive effect of a novel A1 receptor agonist in rat models. As preliminary data we present evidence in

Human social interaction is complicated by ambiguous identities, misinformation, misdirection, and flexible alliances. Additionally, thanks to the internet, authors can post messages from anywhere in the world, in diverse forms, and with different personas. Current solutions are challenged to accurately identify and characterize authors across platforms and data types, let alone infer authorial in ...

DESCRIPTION (provided by applicant): Our goal is to develop an efficient and inexpensive toolkit for ablating or reversibly inactivating specific cell types in the brain or other organs of mammals. We propose new techniques in which the genes for nitroreductase (NTR) or Drosophila allatostatin receptor (AlstR) are delivered into cells using an adeno-associated viral vector (AAV). Both are fusion ...

Currently, the majority of decision-support systems assume normative performance and fail to adapt to individual differences. This is particularly true with respect to affective states and individual beliefs, which can have profound impact on performance, particularly in complex, crisis situations. We propose to develop an Affect and Belief Adaptive Interface System (ABAIS) capable of compensati ...

The Anti-Submarine Warfare Commander (ASWC) has a crucial responsibility to protect against surface and subsurface threats, which requires keeping track of contacts and making safety-critical decisions. The Undersea Warfare Decision Support System (USW-DSS) supports the ASWC and his team by providing a"Common Tactical Picture"via the Master Tactical Plot (MTP). However, evolving sensor and data fu ...

DESCRIPTION (provided by applicant): Radikal Therapeutics is developing a novel small molecule therapy (R-801) for neonatal prematurity that triggers an endogenous cytoprotective defense and thereby blocks pulmonary inflammation and acute lung injury (ALI). R-801 is formed from the covalent fusion of 2 moieties with demonstrated tissue protective properties: 1) a mito-K+-ATP channel activating do ...

PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the development of a novel, bioactive polymer for use in ventricular assist devices (VAD), and other long-term blood contacting implantable devices. Although VADs are becoming an important therapeutic option for patients in heart failure, serious problems persist secondary to thromboembolic complications and continue t ...