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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Small Molecule Inhibitors of trans-Translation with Broad Spectrum Antibacterial

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Because of the emergence of resistance to known antibiotics there is a critical need for new antibacterial agents especially against Gram negative pathogens trans Translation is a biochemical pathway that is essential to many bacterial species including Neisseria gonorrhoeae Shigella flexneri and Mycoplasma spp A high throughput assay of trans translatio ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Inhibitors Targeting Early Steps of Human Cytomegalovirus Replication

    SBC: MICROBIOTIX, INC.            Topic: R

    DESCRIPTION provided by applicant Human cytomegalovirus HCMV infection is a major cause of morbidity and mortality in immunosuppressed patients especially recipients of solid organ or bone marrow transplants HCMV infection of neonates is associated with deafness mental retardation and mortality Although five anti viral drugs GCV val GCV CDV PFA Foscarnet have been approved and lice ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Self-assembling density gradients for sickle cell diagnosis in low resource areas

    SBC: DAKTARI DIAGNOSTICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The World Health Organization has recently recognized sickle cell disease as a major global health concern The highest rates of sickle cell disease and sickle cell trait are seen in malaria endemic developing countries which also have the most severe resource constraints especially on clinical laboratory infrastructure Daktari Diagnostics a person vent ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Dendritic Cell-Targeted HIV Vaccine Product

    SBC: AVANT IMMUNOTHERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION This proposal is a unique collaboration between a small but full capability biotechnology company and a premier academic institution and laboratory to develop a novel product for clinical trials to prevent HIV infection This proposal describes a vaccine product aimed to provide a feasible and nontoxic way to elicit strong immunity in humans to HIV proteins and it will provide an ad ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. An intervention to improve adolescent headache self-management

    SBC: Inflexxion, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant A mobile based intervention to improve adolescentsandapos headache self management Abstract Headache pain is a common and significant problem for adolescents King et al As headaches become more frequent and severe the negative impact on happiness increases and adolescents report less satisfaction with their health and with their life Sillampaa ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Fluorescence Lifetime Dynamics to Understand Brain Neural Activities and Behavior

    SBC: ChiSquare Bioimaging, LLC            Topic: 500

    DESCRIPTION provided by applicant The overall objective of the proposed project is to create a compact robust and easy to use device that is capable of sensitive and quantitative detection of fluorescence lifetime indicators of physiological and biochemical dynamics deep in the brain of a freely moving mouse In contrast to fluorescence intensity based methods fluorescence lifetime can delin ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Selective agents against C. difficile infection

    SBC: NOVOBIOTIC PHARMACEUTICALS, LLC            Topic: NIAID

    DESCRIPTION provided by applicant The overall goal of this project is to develop a selective antibiotic against Clostridium difficile the major agent responsible for antibiotic induced diarrhea and colitis The pathogen can be carried in healthy individuals and is kept at bay by gut symbionts Antibiotic treatment suppresses the normal flora but spores of C difficile survive germinate and ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Transitioning Electronic Support for Public Health (ESP) from Lab to Marketplace

    SBC: Commonwealth Informatics, Inc.            Topic: 400

    DESCRIPTION provided by applicant Accurate and complete disease surveillance is critical to enable public health authorities to detect and respond to disease outbreaks epidemics and even bioterrorism events While legally required of healthcare practitioners and practices most notifiable disease reporting is still done manually or through limited automated laboratory test result reporting ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. An Open Source Precision Medicine Platform for Cloud Operating Systems

    SBC: CUROVERSE, INC.            Topic: 400

    DESCRIPTION provided by applicant Rapid improvements in DNA sequencing and synthesis have the potential to usher in a new era of precision medicine To realize this vision however we must re imagine the computational and storage infrastructure used to manage and extract actionable results from the massive data sets made possible by widely available advances in DNA sequencing and synthetic bio ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Electronics and computational hardware for ultra-high channel count electrophysio

    SBC: Leaflabs, LLC            Topic: 101

    DESCRIPTION provided by applicant The advent of in vivo multielectrode recording has indicated the importance of recording from large populations of neurons As a result there is much interest in creating new kinds of in vivo multielectrode arrays including the polytrode new kinds of microfabricated electrode arrays and new kinds of ultradense D electrode array And yet innovation on the ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health

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