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PROJECT SUMMARY ABSTRACTImage guided surgery using invisible near infraredNIRlight is in the midst of a renaissanceMultiple commercial imaging systemsincluding Curadel s state of the art FLAREsystemare available for preclinicalveterinaryand human surgeryHoweverthe ultimate success of the field will depend on innovative NIR fluorophores that solve important clinical problemsCuradel has invented a n ...

76088S The currently-used transparent conducting oxide electrode for OLED construction is very expensive. It is desired not only to lower the electrode material cost, but also to lower its electrical resistivity and increase its optical transmissiveness. In order to improve the cost and efficiency of OLEDs for solid-state lighting, this project will develop an alternate transparent conducting ...

Triton Systems will develop an inductive link for use in Navy aircrafts to send configuration data to individual rockets within a launcher before launch. The proposed solution will remove the need for umbilicals on the current system and provide a wireless connectivity capability. During Phase I, Triton proposes to build a test model to demonstrate our systems capability to send wireless data to i ...

Project Summary The goal of this project is to significantly enhance our understanding and treatment of inadequate balance responses in the elderly and in patients with neurological impairments following external perturbations such as a slip or trip Our laboratory studies have shown that balance responses can be improved with practice in the elderly and in patients with Parkinsonandapos s disease ...

DESCRIPTION (provided by applicant): More than 130,000 cases of colorectal cancer are diagnosed in the United States each year, and over 50,000 deaths result from it, making this form of cancer the second leading cause of cancer deaths. The lifetime risk of developing colorectal cancer is about 1 in 20. Although this disease is treatable if diagnosed early by colonoscopy, most people with colon ca ...

DESCRIPTION (provided by applicant): This SBIR aims to develop a quantitative in vivo zebrafish hair cell assay that can be used to predict drug induced ototoxicity in humans and to identify potential otoprotective agents. Zebrafish is a good animal model since neuromast hair cells in zebrafish, located in stereotypical positions in the head and trunk region, are structurally and functionally simi ...

DESCRIPTION (provided by applicant): Neuronal systems are sensitive to oxidation. Oxidative damage to biochemical structures of nerve cells has been identified in a large number of neurodegenerative diseases, including stroke, brain trauma, spinal cord injury, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's and Huntington's disease. These diseases are associated with high morbi ...

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The Phase II program will build on technical achievements of Phase I and extend the process to producing 2G filamentized wires optimized for targeted military applications. This is a complex undertaking due to the variety of military and commercial applications with different operating regimes and ac loss requirements. The proposed filament arrangement appears ideally suited for a fine filamentar ...

Future NASA programs like Tertiary Planet Finder (TPF) require high-density deformable mirrors with up to 16,000 actuators to enable direct imaging of planets around distant stars. Xinetics has been developing high-density module actuator arrays that will enable deformable mirrors to be fabricated with array sizes up to 128 by 128. These monolithic actuator arrays have eliminated the need for disc ...