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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 378: PRORAD- A Mobile Application for Patient Related Outcomes of Radiotherapy

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer patients receiving radiation therapy experience toxic side effects of the radiation, and sensitivity to radiation is variable across both patients and tumors, and is poorly understood. This Phase I SBIR project aims to design and demonstrate the feasibility of a Patient Reported Outcome mobile application for surveillance of RADiotherapy toxicity (PRORAD) that integrates NIH's Patient Repor ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 374: Sustained Delivery of PARP Inhibitors for Cancer Chemoprevention

    SBC: TheraNano LLC            Topic: NCI

    Here we propose to study two injectable formulations that provide different delivery routes for Talazoparib, potent PAPR inhibitor: An implant, InCeT-Talazoparib, which can be injected directly in the tumor where it will act as a sustained release depot of Talazoparib over a prolonged period of approximately 30 days. It delivers 100% of the drug to the tumor site with almost no systemic toxicity. ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

    SBC: Imago Systems, Inc.            Topic: NCI

    Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 343- Cognitive Assessment and Monitoring Platform For Integrative Research (CAMPFIRE II)

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer survivors commonly report cognitive impairments following chemotherapy. With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment. This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits. To address ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Analytical Tools and Approaches for (Multidimensional) Scholarly Research Assessment and Decision Support in the Biomedical Enterprise

    SBC: NET ESOLUTIONS CORPORATION            Topic: NIDA

    NIHthrough NIDAseeks advanced tools that could be broadly used by the life science community and generate results that would be understood by non scientists as well as professional evaluatorsIn Phase Ithe Contractor completed initial development of ERNIEan accessible big data platform integrating multiple data sources and associated methods for quantitative description of research that would facil ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. System for the Spec. of Acute THC Imp. Using Val. Alg.

    SBC: Charles River Analytics, Inc.            Topic: NIDA

    NIH through NIDA solicits the research and development of digital markers for detection of marijuana intoxication and cognitive impairmentIn this Project the ContractorCharles River Analyticsin partnership with the SubcontractorMcLean Hospitalproposes to design and demonstrate a prototype system for the Specification of Acute THC Impairment using Validated AlgorithmsSATIVASATIVAingests data across ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Measure of Dysfunctional Retinal Ganglion Cell Response

    SBC: Valenti, Denise            Topic: NIDA

    NIH through NIDA solicits the research and development of digital markers for detection of marijuana intoxication and cognitive impairmentIn this project the Contractor will develop and clinically validate a technology that indirectly tests retinal ganglion cell functionThe sensory psychomotor signal in the smartphone application named IMMAD is a visual field test using a small square with stripes ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. To develop a nanoSPRi sparing assay.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Proposes to develop a novelstandardized immune assay that improves monitoring of several biomarkerscytokinesassociated with immunologic pathways of AD with the constraint of having a limited amount of biological samplesThis overall goal is supported by the following program objectivesPhase IDemonstrate proof of concept of nanoSPRiSAas a sensitive and efficient technique in assessing cytokines in h ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Reagents for Immunologic Analysis of Non-mammalian Models

    SBC: Protein Innovation Labs, Inc.            Topic: NIAID

    The zebrafish is as an extraordinary model organism that provides unique opportunities for probing vertebrate biologywith direct implications for human physiology and diseaseThere exists a significant need to enhance and broaden the utility of this model with the development of new tools and strategiesNotablyantibodies are available for fewer thanof theknown zebrafish proteinsand the majority of t ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. The purpose of this contract is to evaluate and modulate the molecular pathways involved in regulating and enhancing HIV envelope/antigen expression in mammalian cell lines and to accelerate development of purification platforms in a cGMP manufacturing se

    SBC: Anatagen Pharmaceuticals, Inc.            Topic: NIAID

    HIVthe virus that causes AIDSis one of the world s most serious health and development challengesAccording to UNAIDSthere were approximatelymillion people worldwide living with HIV AIDS at the end ofThe vast majority of people living with HIV are in lowto middle income countriesparticularly in sub Saharan AfricaA low cost vaccine is the preferred response to protect the human populationHoweverdesp ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health

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