Award Data

THE OBJECTIVE OF THIS PROGRAM IS TO DESIGN AND BUILD A STAPLER FOR PERFORMING END-TO-END AND END-TO-SIDE ANASTOMOSES ON MEDIUM TO LARGE VESSELS, AND FOR REPAIRING BLOOD VESSELS AND VASCULAR ANEURYSMS, AND TO DEVELOP A SURGICAL PROTOCOL FOR ITS USE. THE METHOD PROPOSED USES A SPECIAL STAPLER AND CONFIGURATION OF STAPLES WHICH MINIMIZESBLOOD CONTACT WITH THE STAPLES, DOES NOT RESTRICT THE FLOW OF BL ...

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MANY DISABLED INDIVIDUALS ARE CURRENTLY BENEFITTING FROM THEFIELD OF THERAPY CALLED THERAPEUTIC RECREATION. EVERY MAJORREHABILITATION CENTER HAS A SEPARATE AND GROWING RECREATION THERAPY DEPARTMENT AS THIS FIELD OF THERAPY GAINS RECOGNI- HAVE SPECIAL EQUIPMENT IN ORDER TO PARTICIPATE. THE DIFFICULTY IN FINDING SUCH EQUIPMENT IS PERSONALLY UNDERSTOOD BY THE PRINCIPAL INVESTIGATOR, WHO WAS PARALYZED ...

THERE IS A NEED FOR A CORONARY-ARTERY DISEASE SCREENING METHOD NOT REQUIRING THE RISK OF AN ARTERIAL CATHETER. DIGITAL-SUBTRACTION RADIOGRAPHS USING IODINE-K-EDGE SUBTRACTION SUFFER FROM LOW X-RAY INTENSITIES AND REQUIRE LARGE IODINE CONCENTRATIONS PRECLUDING NON-INVASIVE TECHNIQUES. BRIGHTER X-RAY SOURCES ARE NEEDED. WE PROPOSE TO CONDUCT AN EVALUATION OF METAL OXIDES AS CHARACTERISTIC-LINE X-RAY ...

THE HISPANIC HEALTH AND NUTRITION EXAMINATION SURVEY (HHANES) CONTAINS A WEALTH OF INFORMATION FOR THE CANCER RESEARCH PROFESSIONAL. THE UTILITY OF THIS DATA BASE CAN BE SIGNIFICANTLY IMPROVED BY PROVIDING A SIMPLE USER INTERFACE SOFTWARE PACKAGE THAT CONVERTS THE DATA INTO USABLE INPUT FOR A COMMERCIAL RELATIONAL DATA BASE MANAGEMENT SYSTEM (RDBMS). ONCE THE HHANES DATA HAS BEEN CONVERTED INTO TH ...

AS PART OF A COLLABORATIVE EFFORT WITH THE DEPARTMENT OF RADIOLOGY AT THE MASSACHUSETTS GENERAL HOSPITAL, ADVANCED MAGNETICS INTENDS TO ASSESS THE POTENTIAL OF LIVER-TARGETED,FERRITE-BASED CONTRAST AGENTS TO ENHANCE THE POTENTIAL OF MAGNETIC RESONANCE (MR) IMAGING FOR DETECTION OF LIVER METASTASES USING A RAT TUMOR MODEL. ALTHOUGH MOST STUDIES WITH MR CONTRAST AGENTS HAVE INVOLVED ONLY IONS OR ION ...

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HOME CARE INHALATION THERAPY REQUIRES A READY SUPPLY OF OXYGEN FOR PATIENT COMFORT. UNFORTUNATELY, AVAILABLE TECHNIQUES FOR SUPPLYING OXYGEN ALL SUFFER FROM MAJOR DRAW- BACKS. THE MOST NOTABLE COMMON PROBLEM IS EXCESSIVE WEIGHT WHICH LIMITS PATIENT MOBILITY BOTH INSIDE AND OUTSIDE THE HOME. THE OBJECTIVE OF THIS RESEARCH IS TO DEMONSTRATE THE FEASIBILITY OF DEVELOPING A TRULY PORTABLE HOME CARE UN ...

THIS RESEARCH WILL CONTRIBUTE TO THE DEVELOPMENT OF A WHOLE-BODY MAGNETIC RESONANCE IMAGING (MRI) SYSTEM CAPABLE OF ACQUIRING COMPLETE TOMOGRAPHIC PROTON IMAGES IN ABOUT 50 MILLISECONDS. IN PARTICULAR, THE POTENTIAL UTILIZATION OF 180-DEGREE RADIOFREQUENCY PULSES IS ADDRESSED AS A MEANS OF ELIMINATING ARTIFACTS THAT ARISE AS A RESULT OF MAGNETIC FIELD STRENGTHS MANDATED BY SIGNAL-TO-NOISE RATIO AN ...

A CHARACTERISTIC FEATURE OF MANY RHEUMATIC DISEASES IS THE PRESENCE OF CIRCULATING ANTINUCLEAR ANTIBODIES. ASSAYS BASED ON THE MEASUREMENT OF THESE ANTIBODIES ARE ESTABLISHED IN THE CLINICAL LABORATORY FOR THE DIAGNOSIS OF THESE DISEASES, BUT OFTEN WITHOUT THE BENEFIT OF HAVING WELL-CHARACTERIZED OR ISOLATED TARGET ANTIGENS. ONE SUCH AUTOIMMUNE DISEASE IS SCLERODERMA OR PROGRESSIVE SYSTEMIC SCLERO ...