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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. 12-lead MRI-Compatible ECG for physiological monitoring and scanner synchronizati

    SBC: E-TROLZ, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): This SBIR project aims to develop an MRI-compatible 12-lead ECG system. Such a system will provide greatly improved physiological monitoring inside the MRI, which is important for imaging severely ill patients (stroke, spine, patients with ischemic histories), and is also key to future MRI-guided interventions and surgeries. Current MRI-compatible ECG monit ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are primarily comprised of polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Unfortunately, these grafts continue to have high failure rates due to secondary complications associated with acute thromboses and incomplete, unregulated cellular prol ...

    STTR Phase II 2011 Department of Health and Human Services
  3. A Clinical Decision Support Tool for Electronic Health Records

    SBC: Inflexxion, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Substance abuse treatment is often complicated by problems such as depression, family and interpersonal conflicts, and legal issues. When these issues are addressed with effective, evidence-based treatments (EBTs), outcomes improve. To improve the quality of addiction treatment, experts have called for the adoption of a continuing care management approach, invo ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. A device for rapid, painless, bedside muscle evaluation of children

    SBC: Myolex Inc            Topic: NINDS

    DESCRIPTION (provided by applicant): Our goal is to provide neurologists and other clinicians a method for the rapid, painless, non-invasive evaluation of children with neuromuscular disease. Pediatric neuromuscular disorders include muscular dystrophies, spinal muscular atrophy, and inflammatory myositis, and affect well over 100,000 children in the United States alone. Present-day clinical m ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors


    DESCRIPTION (provided by applicant): Cancer is America's second leading cause of death. Many approved cancer drugs, such as bortezomib (Velcade), are cytotoxic agents that kill normal cells as well as tumor cells. Therapeutic benefit depends on tumor cellsbeing more sensitive than normal cells, thereby allowing clinical responses to be achieved at relatively safe drug doses; however, damage t ...

    STTR Phase I 2011 Department of Health and Human Services
  6. A Guideline Based Tool for Increasing Cancer Screening Rates


    There is a need for better decision support tools to help doctors quickly assess patients' cancer screening status. Colorectal cancer screening is especially difficult to track because there are many screening options that take place over time and in different settings. The proposed research will address this issue by designing a tool that allows doctors to quickly assess patients' screening histo ...

    SBIR Phase I 2011 Department of Health and Human Services

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Infections associated with medical devices can be serious and even fatal. Catheter colonization and production of a biofilm on the surface of a catheter shortly after implantation are normally the prelude for infections. A number of antimicrobial-treated catheters have been developed to combat these infections, however, many of them have limited clinical effica ...

    STTR Phase I 2011 Department of Health and Human Services
  8. A Personal Monitor for Space- and Time-Resolved Measurements of Aerosol Exposure

    SBC: ENERTECHNIX, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): The proposed project will develop and demonstrate a miniaturized, portable aerosol sampler that will collect a series of time- and location-resolved personal exposure samples for conducting research into the relationships among environmental exposure, genetics and health. It will also develop a bench-top assay unit that will perform colorimetric assays for endo ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. A point-of-care device for generating nitric oxide for inhalation


    DESCRIPTION (provided by applicant): Nitric oxide (NO) gas was considered to be a highly toxic pollutant as recently as the 1980s. It is now recognized to be an important messenger molecule in mammalian physiology. Inhaled NO is currently used to treat approximately 25,000 patients per year in this country with pulmonary hypertension. It is safe, effective, but costly. Published studies in which t ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. A Portable High Resolution Detector for Rapid Field Arsenic Test in Drinking Wate

    SBC: AGILTRON, INC.            Topic: NCEH

    DESCRIPTION (provided by applicant): The combination of high toxicity and widespread occurrence has created a pressing need for effective monitoring of arsenic in groundwater. Through this program Agiltron will develop a field deployable monitoring tool based on surface enhanced Raman spectroscopy (SERS) for rapid on-site detection and quantification of arsenic in groundwater. During operation in ...

    SBIR Phase II 2011 Department of Health and Human Services

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