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THE OBJECTIVE OF THIS PROPOSAL IS THE DEVELOPMENT OF A MINIATURE ELECTRICAL CONNECTOR SUITABLE FOR PERMANENT IMPLANTATION IN THE BODY. SUCH A DEVICE IS INTENDED TO SERVE AS A CONNECT/DISCONNECT POINT FOR NEURAL PROSTHESES, ENABLING REPLACEMENT OF FAULTY COMPONENTS WITHOUT NECESSITATING REMOVAL OF AN ENTIRE IMPLANTED SYSTEM. SEVERAL DIFFERENT ELECTRICAL CONNECTORS HAVE BEEN DEVELOPED IN CONJUNCTION ...

THE BASIC FUNCTION OF A SURGICAL SUTURE IS TO MAINTAIN TISSUE APPROXIMATION UNTIL THE WOUND HEALS. IDEALLY, UPON HEALING, THE SUTURE SHOULD DISAPPEAR, LEAVING NO TRACE OF ITS PRIOR EXISTENCE AND THUS MINIMIZING UNDESIRABLE FOREIGN BODY REACTIONS. RECENTLY, SEVERAL SYNTHETIC ABSORBABLE POLYMERIC SUTURE MATERIALS WERE DEVELOPED THAT DEMONSTRATED SATISFACTION FOR MOST OF THE WOUND CLOSURE REQUIREMENT ...

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HEMODIALYSIS PATIENTS ARE AT RISK FOR TOXICITY FROM VARIOUS DISINFECTING, STERILIZING, AND CLEANING AGENTS USED IN REPROCESSING HEMODIALYZERS. THE AIM OF THE PROJECT IS TODEVELOP A NONTOXIC BIOCIDE CAPABLE OF EFFECTIVE, ECONOMICAL STERILIZATION AND CHEMICAL CLEANING OF DIALYZERS. THE POTENTIAL EXISTS FOR A CHEMICAL FORMULATION THAT HAS THESE PROPERTIES AND MAINTAINS THE INTEGRITY OF THE UNIT WHILE ...

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ONE OF THE MOST ACTIVE AND CHALLENGING FIELDS IN MOLECULAR BIOLOGY TODAY IS THE GENETIC STUDY OF EUKARYOTIC SYSTEMS. AN ESSENTIAL, BUT OFTEN RATE LIMITING STEP IN THIS AREA IS THE SCREENING OF DNA LIBRARIES FOR GENE MAPPING. THIS PROCEDURE USES RADIOLABEL HYBRIDIZATION TECHNIQUES AND AUTORADIOGRAPHY TO ACHIEVE THE REQUIRED SENSITIVITY AND SPECIFICITY. THE PARTICULAR PART OF THE PROCESS THAT THIS P ...

ACUTE RENAL FAILURE IS A MAJOR CONTRIBUTING CAUSE OF DEATH IN PATIENTS IN THE INTENSIVE CARE UNIT PARTLY DUE TO THE LACK OF A SIMPLE, RAPID METHOD OF ASSESSING KIDNEY FUNCTION. IT WOULD THEREFORE BE EXTREMELY USEFUL IF A DIRECT MEASUREMENT OF RENAL FUNCTION COULD BE PERFORMED AT REGULAR INTERVALS SO THAT THE NEED FOR ANY MEDICAL OR SURGICAL INTERVENTION COULD BE IDENTIFIED BEFORE ANY SIGNIFICANT D ...

RECENTLY, PRELIMINARY RESEARCH USING CYCLOTRON-PRODUCED, POSITRON-EMITTING RADIOLABELS HAS BEEN CONDUCTED AT THE MEMORIAL SLOAN-KETTERING CANCER CENTER TO DEVELOP A RABBIT/RAT CORNEAL IMPLANT METHOD TO STUDY HUMAN TUMOR ANGIOGENESIS AND METABOLISM. THIS TECHNIQUE IS DESIGNED TO DETERMINE THE DIRECT IMPACT OF CHEMOTHERAPEUTIC STRATEGIES ON HUMAN BRAIN TUMORS. IT IS HOPED THAT DRUG SCREENING FOR PAT ...

RADIATION THERAPY HAS BECOME ONE OF THE MOST IMPORTANT TOOLS FOR THE CONTROL OF CANCER, AND AN IMPRESSIVE ARRAY OF SUPPORTING TECHNOLOGIES HAS BEEN DEVELOPED. WHILE MANY OF THESE ACCESSORIES ARE READILY AVAILABLE FROM COMMERCIAL SOURCES, A VERY SIGNIFICANT NUMBER OF THERAPY AIDS HAVE BEENDEVELOPED AT INDIVIDUAL TREATMENT CENTERS AND ARE NOT AVAILABLE COMMERCIALLY, NOR WIDELY KNOWN. THIS SITUATION ...

GEL ELECTROPHORESIS IS ONE OF THE MOST IMPORTANT AND WIDELY USED ANALYTICAL TECHNIQUES FOR THE DETERMINATION OF THE SEQUENCE OF DNA. RECENTLY, THERE HAS BEEN A SIGNIFICANT ADVANCE IN ELECTROPHORESIS TECHNOLOGY THROUGH THE USE OF GEL GEOMETRIES INVOLVING THIN CAPILLARY TUBES. THIS TECHNOLOGY HAS BEEN DEVELOPED INTO A NEW SEPARATION TECHNIQUE, CAPILLARY ZONE ELECTROPHORESIS (CZE), WHICH PROVIDES MUC ...