Award Data

DESCRIPTION (provided by applicant): The ultimate objective of this proposed program is the commercialization of a universal transcutaneous energy transfer (TET) system with a high performance implantable battery. This integrated power system will be adapt able to a host of next generation fully implantable mechanical circulatory support (MCS) systems. To date, fully implantable systems (i.e. the ...

DESCRIPTION (provided by applicant): Ischemic ventricular tachycardia (VT) is a contributing cause to more than half of the 300,000 sudden cardiac deaths that occur annually in the United States. Implantable cardioverter defibrillators (ICDs) are the stand ard therapy but they are expensive the total cost of an ICD implant approaches 50,000 and the United States spends more than 2.2B on these im ...

Project Summary Embryonic stem cells offer considerable potential for cell replacement therapy where cells have been lost to injury or disease because of their capacity for continual self renewal and ability to differentiate into virtually any cell type or tissue. Currently, however the process by which human embryonic stem cells (hESCs) differentiate into various mature functional cell types is ...

DESCRIPTION (provided by applicant): Sufficient general clinical knowledge, DNA sequence technology and understanding of genetic mutations for over 2,600 human genes can support beginning the integration of individual genome sequence into clinical practic e for a number of medical specialties. With the 2007 deployment of novel DNA sequence technologies that permit cost-effective interrogation of ...

DESCRIPTION (provided by applicant): Real-Time Image and Dose Guided Radiation Therapy System Development and integration of a real-time image- and dose-guided radiation therapy system is long overdue. Advanced Radiation Therapy has identified an opportuni ty and designed a single system that uses a common platform for imaging the target tissue in real-time, immobilizing the tissue, delivering rad ...

Proliferation of nuclear weapons is a serious threat in the world today. One way to determine the presence of nuclear weapons is to detect neutrons emitted by special nuclear material(SNM) such as highly enriched uranium and weapons grade plutonium. The purpose of this project is to develop improved solid state neutron detectors from CVD diamond for homeland security applications. Phase I work wil ...

Gamma-ray spectrometers consisting of inorganic scintillators coupled to optical detectors such as photomultiplier tubes (PMTs) are an important element of the systems that are used to monitor and prevent the spread of special nuclear materials. Two very important requirements for the scintillation detectors used as gamma-ray spectrometers in homeland security monitoring include high sensitivity a ...

DESCRIPTION (provided by applicant): Radiation Monitoring Devices ( RMD') is developing a digital radiographic imaging technology that is based upon a semiconductor x-ray receptor. The more specific, targeted application is mammographic imaging (including breast tomosynthesis) for which the benefits of this technology will later be described. At the core of this research, RMD is developing the pr ...

DESCRIPTION (provided by applicant): Microfluidic chips, fabricated from low cost polymers, are a promising, emerging technology for synthesis and study of new molecular imaging probes. These chips can contain a variety of microcircuitry and microwells and are capable of manipulating nanoliter samples of reagents and solvents. The microfluidic chips have been designed for a multitude of applicati ...

The use and applications of radiological sources, for power, medical, and defense applications, continuously increases with time. Illicit nuclear materials represent a threat for the safety of the American citizens and the detection and interdiction of a nuclear weapon is a national problem that has not been yet solved. This represents an enormous challenge to current detection methods and monitor ...