Award Data

DESCRIPTION (provided by applicant): The ultimate objective of this proposed program is the commercialization of a universal transcutaneous energy transfer (TET) system with a high performance implantable battery. This integrated power system will be adapt able to a host of next generation fully implantable mechanical circulatory support (MCS) systems. To date, fully implantable systems (i.e. the ...

DESCRIPTION (provided by applicant): Ischemic ventricular tachycardia (VT) is a contributing cause to more than half of the 300,000 sudden cardiac deaths that occur annually in the United States. Implantable cardioverter defibrillators (ICDs) are the stand ard therapy but they are expensive the total cost of an ICD implant approaches 50,000 and the United States spends more than 2.2B on these im ...

Project Summary Embryonic stem cells offer considerable potential for cell replacement therapy where cells have been lost to injury or disease because of their capacity for continual self renewal and ability to differentiate into virtually any cell type or tissue. Currently, however the process by which human embryonic stem cells (hESCs) differentiate into various mature functional cell types is ...

DESCRIPTION (provided by applicant): Sufficient general clinical knowledge, DNA sequence technology and understanding of genetic mutations for over 2,600 human genes can support beginning the integration of individual genome sequence into clinical practic e for a number of medical specialties. With the 2007 deployment of novel DNA sequence technologies that permit cost-effective interrogation of ...

Future lunar and planetary explorations will require the storage of cryogenic propellants, particularly liquid oxygen (LOX) and liquid hydrogen (LH2), in low earth orbit (LEO) for periods of time ranging from days to months, and possibly longer. LEO is a relatively warm thermal environment and without careful thermal management, significant quantities of stored liquid cryogens can be lost due to ...

DESCRIPTION (provided by applicant): Real-Time Image and Dose Guided Radiation Therapy System Development and integration of a real-time image- and dose-guided radiation therapy system is long overdue. Advanced Radiation Therapy has identified an opportuni ty and designed a single system that uses a common platform for imaging the target tissue in real-time, immobilizing the tissue, delivering rad ...

In this proposed SBIR project, we seek to implement the Adaptive Chemistry methodology in existing CFD codes used to investigate the emissions performance of gas turbine engine combustors. We will demonstrate the feasibility of integrating Adaptive Chemistry algorithms to current CFD codes. We will also further develop the Adaptive Chemistry method to take advantage of species reduction enabling e ...

This Small Business Innovation Research Phase I project concerns the development of a multi-wavelength monitor that will provide rapid, real-time measurement of the average aerosol absorption coefficient in the parcel of sample air. This monitor will employ Aerodyne's proprietary Cavity Attenuated Phase Shift spectroscopy technology in order to produce a far simpler, smaller, lower cost alterna ...

We propose to design, build and test an optical extinction monitor for the detection of spacecraft cabin particulates. This monitor will be sensitive to particle sizes ranging from a few nanometer to tens of micrometers in diameter. Designed to utilize commercial off-the-shelf components, the monitor, once calibrated, will require no recalibration and only periodic baseline determinations, a pro ...

Agiltron together with Prof. Michael Rubner's group at MIT is developing a new family of nanoporous, low refractive index coatings for next generation NASA UV anti-reflection (AR) application on large plastic optics. The initial application is intended for 2.5 m diameter PMMA Fresnel lenses which NASA anaticipates as part of the EUSO mission cosmic ray telescope. The new thin film technology comb ...