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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

    STTR Phase I 2008 Department of Health and Human Services
  2. Ph.II: Innovative Methods for Function and Disability Assessment

    SBC: CRECare LLC            Topic: N/A

    DESCRIPTION (provided by applicant): We propose applying innovative measurement technology to develop and disseminate a comprehensive function and disability assessment instrument for use in gerontological research and practice. This technology offers an e ffective method to resolve the classic conflict between practicality and psychometric adequacy faced by traditional standardized outcome measur ...

    STTR Phase II 2008 Department of Health and Human Services
  3. Phase II: COMPUTER ADAPTIVE TESTING OF PEDIATRIC SELF CARE AND SOCIAL FUNCTION

    SBC: CRECare LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Our objective is to achieve a major advance in the technology used to assess disability in children and youth. Measurement and practical requirements for identifying disability and evaluating individual progress across pediatric age groups and care settings present a serious dilemma to current fixed-item survey instruments. In Phase I proposals, we have develo ...

    STTR Phase II 2008 Department of Health and Human Services
  4. Transmucosal Intra-Oral Drug Delivery System for THC

    SBC: ElSohly Laboratories, Incorporated            Topic: N/A

    DESCRIPTION (provided by applicant): Delta-9-Tetrahydrocannabinol (THC), the active ingredient in the cannabis plant, has a wide range of pharmacological properties of therapeutic value. The drug has been approved by the Food and Drug Administration (FDA) (Marinol(r) soft gelatin capsules) for the treatment of nausea and vomiting associated with chemotherapy and for appetite stimulation in AIDS p ...

    STTR Phase II 2008 Department of Health and Human Services
  5. Alkoxylamine nucleosides for sequencing by synthesis

    SBC: INTELLIGENT BIO-SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Sequencing during synthesis (SdS) is an architecture for massively parallel DNA sequencing that has the strong potential of lowering the cost of sequencing enough to allow individuals access to their own genetic heritag e as a way of personalizing their medical care. Thus far, however, higher-throughput next-generation sequencing systems are relatively expensiv ...

    STTR Phase II 2008 Department of Health and Human Services
  6. Integrated Maglev Pump-Oxygenator for Respiratory Support

    SBC: LEVITRONIX, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Chronic lung disease remains America's third largest cause of death. Adult respiratory distress syndrome (ARDS) alone afflicts approximately 150,000 patients every year with a mortality rate between 30-70%. Current ther apy for respiratory failure includes mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Mechanical ventilation is effective ...

    STTR Phase II 2008 Department of Health and Human Services
  7. Endoscopically-guided optical coherence tomography for early cancer screening

    SBC: Physical Sciences Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal addresses a need for an improved technology for early cancer detection and rapid screening. Recent advances in nanotechnology and high resolution imaging have led to the development of new investigative t ools capable of probing biological tissues at the cellular level. These tools can be used to localize abnormal neoplastic cells and expedite th ...

    STTR Phase I 2008 Department of Health and Human Services
  8. Enhanced Contrast Imaging for Screening of Early Pancreatic Cancer

    SBC: Physical Sciences Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal addresses a real need for an improved technology for early detection and rapid screening of ductal pancreatic cancer. Very recent advances in nanotechnology and high resolution optical coherence tomography (OCT) imaging have led to the development of new investigative tools capable of probing biological tissues at the cellular level. These tools ...

    STTR Phase I 2008 Department of Health and Human Services
  9. The Crystal Optimizer: Kinetic Control of Protein Crystallization

    SBC: RAINDANCE TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Protein crystallization remains a bottleneck in the goal to determine the protein's structure. A microfluidic device denoted the Crystal Optimizer (XOpt) has been developed to optimize the kinetic pathway for the nuclea tion and growth of protein crystals once the lead conditions have been identified by other screening methods. The device drives each of hundred ...

    STTR Phase I 2008 Department of Health and Human Services
  10. Fully Compensated Dynamic Shim System for In Vivo MRI and MRS

    SBC: Resonance Research, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Functional MRI, diffusion MRI and MR spectroscopy and spectroscopic imaging have great potential for the study and diagnosis of disease and injury, and guiding surgical therapy. All of these methods benefit greatly fro m the added sensitivity, resolution and contrast from high field strength magnets (3T and above). However, the advantages of higher magnetic fi ...

    STTR Phase I 2008 Department of Health and Human Services

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