Award Data

Program SummaryAmyotrophic lateral sclerosisALSaffects an estimatedindividuals in theUnited States andworldwideThe disease is characterized by loss of motor neurons leadingto loss of muscle control and muscle wastingPatients typically progress from diagnosis todeath inyearsWhile there are two approved therapies to treat ALStheir effectsare limitedThe lack of available treatments for ALS patients r ...

ABSTRACT Fungal keratitisprimarily caused by CandidaFusariumor Aspergillus speciesis a leading cause of blindness among corneal diseasesAmphotericin BAmBremains the gold standard in the treatment of Candida keratitis and is also the fallback option for other corneal fungal infectionsAlthough widely used off label in ocular infectionsophthalmic AmB formulations are not available commerciallyThe com ...

PROJECT SUMMARY Imaging forms the backbone of living subjects researchLiving subjects research is both essential to the progress of translational medicine and very expensiveThe research community actively seeks to develop and validate new clinical endpoints to solve a range of etiologynatural historydiagnostic and prognostic problemsThis project aims to develop and commercialize LATTICEan Electron ...

PROJECT SUMMARY ABSTRACT Opioid Use DisorderOUDis a key driver of the current opioid epidemic in the United StatesNearlyof individuals with OUD do not receive treatmentBuprenorphine Medication Assisted TreatmentMATis an effective form of care for OUDBuprenorphine ameliorates craving and withdrawaland reduces illicit opioid usemortalityand problems associated with drug useHoweveradoption of bupreno ...

ProprietaryThis proposal includes trade secrets and other proprietary or confidential information of Highland Instruments and is being provided for use by the National Institutes of HealthNIHfor the sole purpose of evaluating this SBIR proposalNo other rights are conferredThis proposal andthe trade secrets and other proprietary or confidential information contained herein shal further not be discl ...

Project Summary The elderly population is rapidly increasing worldwide and those over 60 years old are expected to comprise 20% of the total population by 2050. These demographic changes will focus healthcare needs on those conditions more prevalent in the elderly. Chronic wounds, such as venous leg ulcers, pressure ulcers and diabetic ulcers are over-represented in the elderly population and even ...

Abstract Overmillion Americans agedor older reported opioid misuse inOverpeople died due to opioid related overdoses inupfromtoPreventing the onset of opioid misuse is critical for young adultswho representmillion past year opioid misusersOpioid misuse in this developmental period can negatively affect mentalphysicaland social well being and can lead to morbidity and mortality due to overdoseYoung ...

Project Summary The objective of this project is to demonstrate feasibility of a novel platform technology using ultrasonic waves for wireless bidirectional real time communication and powering of a Bilateral Deep Brain StimulationDBSsystem with remote patient monitoringDBS has become an established neurosurgical procedure with overpatients treated worldwideDBS has been shown to improve Parkinsona ...

Project Summary Neuropathy is an acquired disease that can lead to debilitating chronic pain affectingtoof the general populationAmong patients with symptomatic neuropathysleep disturbancesanxiety and depression are commonnegatively impacting quality of lifeDiabetes is a leading cause of neuropathy and is expected to become more prevalent as the incidence of diabetes increasesChemotherapy induced ...

PROJECT SUMMARY Needle electromyographyEMGremains the standard approach for assessing neuromuscular diseaseWhile the technique has proven to be clinically valuable over the lastyearsit has important limitationsThese include its not being sensitive to alterations in muscle composition and structureits inability to assess the contractile apparatus of muscleand its subjective nature with an inter rat ...