Award Data

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project will be to provide the refrigerant industry with the first commercial designs for separating complex, multi-component, azeotropic refrigerant mixtures for economical recycling. The American Innovation and Manufacturing Act authorizes the Environmental Protection Agency (EPA) to phase down prod ...

The broader/commercial impact of this Small Business Technology Transfer (STTR) Phase I project is to increase the volume and improve the accuracy of data on the world’s forests. Presently, when collecting data on forests, surveyors must choose between slow, laborious methods, or quick but inaccurate ones. This project uses recent advances in sensors and machine learning to greatly improve data ...

C56-30a-273585Electron cyclotron resonance heating is a key fusion technology for: a) plasma heating; b) instability control, to stabilize instabilities such as those from Neoclassical Tearing Modes; and c) electron cyclotron assisted startup. Gyrotrons are a proven vacuum tube technology that can generate sufficient power during continuous operation to satisfy these requirements. In this Phase I ...

A quad-active-bridge (QAB) multiport converter will be developed based on an innovative circuit topology, a high-frequency planar magnetic transformer, and the latest generation of wide bandgap (WBG) transistors. The WBG-based QAB converter will provide a high-efficiency and ultra-compact interface capable of connecting with an array of photovoltaic (PV) panels, battery packs, electric vehicles (E ...

Quantum computers has the potential to revolutionize computing, solving problems in chemistry, material science and optimization that are beyond the reach of today's most powerful supercomputers. However, we are still in the early phase of the technology development, and today’s quantum hardware systems suffer from drift and imperfections and require frequent calibrations to operate properly. Th ...

Project Summary Surgery and acute post-operative pain are major contributors to persistent pain, chronic pain, and opioid dependence. Currently, there are no products on the market in the United States that can be used to monitor surgical nociception. Existing products use indicators that are susceptible to intraoperative influences such as blood loss, anesthetic drugs and antihypertensives. This ...

Project Summary / Abstract Nerve injuries arising from trauma, disease, or as a surgical necessity, lead most often to permanent loss of some or all functions mediated by the injured nerves. 50,000 peripheral nerve procedures are performed every year in the US, and 300,000 across Europe. After complete transection of a nerve, the optimal clinical procedure for nerve repair remains the surgical end ...

Project Summary Low back pain (LBP) is one of the most common reasons for physician visits in the USA. A substantial number of chronic LBP (cLBP) patients do not adequately respond to current treatment options. Thus, the development of new treatments for cLBP is urgently needed. The use of imagery to treat illness, including chronic pain, is one of the oldest medical practices. Although still unde ...

Infection with the bacterium C. difficile is the most common and increasingly prevalent cause of diarrhea. In the United States, cases of C. difficile infection (CDI) are estimated to number 500,000 annually and to result in an estimated 15,000 to 30,000 deaths. The cost of these cases is thought to exceed $4.8 billion annually. CDI continues to cause discomfort, serious illness and sometimes deat ...

PROJECT SUMMARY The epidermal growth factor receptor (EGFR) gene is mutated and/or amplified in majority of primary glioblastoma (GBM). While EGFR-mutant GBM cancer cells are dependent on EGFR signaling for survival, numerous small molecule EGFR tyrosine kinase inhibitors (TKIs) have failed to show efficacy in this disease. There are two main reasons for these failures: i) Many of these EGFR-TKIs ...