Award Data

THREE TO FOUR MILLION YOUNG CHILDREN FROM ALL LEVELS OF SOCIETY ARE EXPOSED TO ENVIRONMENTAL SOURCES OF LEAD AT CONCENTRATIONS THAT PLACE THEM AT RISK FOR ADVERSE HEALTH EFFECTS. YET, THERE IS NO TOOL AVAILABLE FOR MEASURING TOTAL PEDIATRIC BODY BURDEN OF LEAD. THIS PROJECT WILL DEVELOP AN X-RAY FLUORESCENCE (XRF) INSTRUMENT THAT WILL ALLOW MEASUREMENT OF BODY LEAD BURDEN IN CHILDREN IN VIVO AND N ...

CENTRIFUGAL BLOOD PUMPS HAVE BEEN USED EXTENSIVELY FOR SHORT-TERM CIRCULATORY ASSISTANCE AND PERFUSION PUMPS. THEIR UTILITY FOR LONG-TERM VENTRICULAR ASSISTANCE IS LIMITED BY THROMBUS FORMATION AT THE SHAFT SEAL. ABIOMED, INC., WILL DEVELOP A MAGNETICALLY SUSPENDED CENTRIFUGAL BLOOD PUMP THAT WILL HAVE NO SHAFT SEAL AND BE SUITABLE FOR LONG-TERM CIRCULATORY SUPPORT IN EITHER AN IMPLANTED OR EXTRAC ...

THIS RESEARCH WILL DEMONSTRATE THAT A NEW 1.9-MU M LASER CAN PERFORM LASER-ASSISTED VASCULAR ANASTOMOSES OF SMALL-DIAMETER VESSELS (1 TO 5 MM). THE 1.9-MU M LIGHT HAS OPTIMAL ABSORPTION CHARACTERISTICS TO ENSURE AN EVEN DEPOSITION OF ENERGY IN THE VESSEL WALL. THIS SHOULD RESULTIN A MORE DESIRED TEMPERATURE PROFILE IN THE REGION OF THE ANASTOMOSIS WHEN COMPARED WITH ALTERNATIVE SOURCES. THE PROPOS ...

THE OBJECTIVE IS TO DEVELOP A PERIODONTAL PROBE CAPABLE OF MEASURING SITE TEMPERATURE AND POCKET DEPTH SIMULTANEOUSLY AND AUTOMATICALLY. THE PROBE IS INTENDED TO BE A RAPID SCREENING DEVICE FOR THE STATE OF PERIODONTAL HEALTH DURING ROUTINE DENTAL EXAMINATIONS. STUDIES HAVE SHOWN THAT THE INFLAMED SULCUS IS ACCOMPANIED BY ELEVATED SITE TEMPERATURES. POCKET DEPTHS ARE ROUTINELY MEASURED DURING DENT ...

We live in a three dimensional world, where we can go around an object and observe it from all angles. The current displays: TVs, movie screens, and computer monitors are all two dimensional devices. These displays give us only "flattened" realities. The missing third dimension carries with it tremendous amounts of information that is absolutely vital to the users. ACT has demonstrated the princip ...

THE PROPOSED PHASE I EFFORT CONSISTS OF ANALYSIS AND EVALUATION OF TECHNIQUES FOR MEASUREMENT OF ACOUSTIC SENSOR POSITIONS IN LONG TOWEDARRAYS FOR USE IN REDUCING PERFORMANCE DEGRADATIONS DUE TO ARRAY MOTIONS AND DISTORTION. PRESENT AND FUTURE ARRAY DESIGNS AND OPERATING ENVIRONMENTS WILL BE CONSIDERED, WITH SPECIFIC ATTENTION TO NONACOUSTIC SENSOR SUITES AND CAPABILITIES. A SURVEY OF SHAPE ESTIMA ...

INNOVATIVE APPROACHES ARE PROPOSED FOR ANALYTICAL INVESTIGATION AND EVALUATION IN A PHASE I EFFORT TO DEVELOP MULTIPATH AND CLUTTER SUPPRESSION TECHNIQUES FOR LOW SURFACE GRAZING ANGLE CMW AND MMW RADAR DIRECT OR DIFFERENTIAL GUIDANCE OF A MISSILE TO A TARGET IN THEATER MISSILE DEFENSE APPLICATIONS. THE RADAR IS EITHER MISSILE-BONE OR SITUATED IN THE MISSILE LAUNCH AREA OR ON THE LAUNCH PLATFORM. ...

1Innovative techniques for radar high angle resolution are proposed for investigation in a Phase I effort to enable the resolution of the direction of arrival (DOA) of returns from multiple targets that fall within one beamwidth and within the same range and Doppler Cells. The techniques proposed emphasize the pursuit for optimal utilization of available aperture space, by a combination of arrange ...

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THE OBJECT OF THIS RESEARCH IS TO DEVELOP AN ANTI-HEPATITIS B VIRUS PRO-DRUG WHICH WILL CONCENTRATE IN THE INFECTED LIVER TISSUE BY BINDING THE HEPATIC ASIALOGLYCOPROTEIN RECEPTOR AND RELEASING THE ACTIVE FORM OF THE DRUG IN THE HEPATOCYTE. TOWARD THIS END, A NUMBER OF ADENOSINE ARABINOFURANOSIDE/ARABINOGALACTAN CONJUGATES WILL BE SYNTHESIZED. THE CONJUGATES WILL BE EVALUATED AS SUITABLE PRODRUGS ...