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CYSTIC FIBROSIS (CF) IS A LETHAL GENETIC DISEASE AFFECTING THE WHITE POPULATION IN THE UNITED STATES AND EUROPE. THE GOAL OF THIS PROJECT IS TO USE RECOMBINANT DNA TECHNOLOGY TO GAIN THE INFORMATION NECESSARY TO DESIGN A TEST FOR CF GENE CARRIERS. IN THIS PROJECT LYMPHOBLASTOID CELL LINES WILL BE ESTABLISHES FROM MEMBERS OF LARGE CF PEDIGREES TO PROVIDE A SOURCE OF DNA FROM FAMILY MEMBERS. LATER, ...

THE LONG-RANGE PURPOSE OF THIS RESEARCH IS TO ENABLE THE DESIGN OF BETTER VIBROTACTILE COMMUNICATION AIDS FOR THE PROFOUNDLY DEAF. THE IMMEDIATE GOAL IS TO ASSESS THE POTENTIAL OF PIEZOELECTRIC BIMORPHS AS A MEANS OF IMPLEMENTING MORE APPROPRIATE VIBROTACTILE TRANSDUCERS THAN ARE AVAILABLE. THEORETICAL MODELS OF VARIOUS CONFIGURATIONSOF BIMORPHS INTERFACING WITH THE SKIN WILL BE GENERATED, MODELS ...

"CRYSTAL IDENIFICATION SENSORS FOR PET IMAGING" SBIR-DRR AND/OR NIMH:BRAIN AND BODY IMAGING. POSITRON EMMISSION TOMOGRAPHY (PET) IS A NONINVASIVE MEDICAL IMAGING TECHNIQUE WHICH PROVIDES A THREE DIMENSIONAL IMAGE OF RADIO PHARMACEUTICALS DISBURSED IN THE BODY. IT IS BECOMING AN IMPORTANT FUNDAMENTAL TOOL FOR BOTH CLINICAL DIAGNOSIS AND MEDICAL RESEARCH. THE HEART OF THIS INSTRUMENT IS A LARGE ARRA ...

APPROXIMATELY 5% OF THE U.S. POPULATION HAVE DISFIGURING BIRTHMARKS. RECENTLY, LASERS HAVE BEEN USED TO HEAT AND DESTROY NEVUS FLAMMEUS, A COMMON CONGENITAL HEMANGIOMA, MOSTOFTEN CALLED PORT WINE STAIN (PWS). NOT ALL PWS BIRTHMARKS RESPOND TO TREATMENT WITH THE COMMONLY USED ARGON-ION LASER.OLDER PATIENTS AND THOSE WITH PURPLE LESIONS RESPOND BETTER AND WITH LESS RISK THAN YOUNGER PATIENTS OR THOS ...

THE AIM OF THE PROPOSED RESEARCH IS TO CONDUCT LABORATORY INVESTIGATIONS LEADING TO AN AUTOMATED PERIODONTAL POCKET DEPTH AND ATTACHMENT LEVEL MEASURING DEVICE. THE DESIGN FEATURES INCLUDE: AUTOMATIC DETECTION OF THE CEMENTOENAMEL JUNCTION, CONSTANT ADJUSTABLE PROBING FORCE, AND AUTOMATIC RECORDING OF THE ATTACHMENT LEVEL. ALTHOUGH THE CONVENTIONAL PROBE IS WIDELY USED, THE ERRORS INHERENT IN ITS ...

THE APPLICANT PROPOSES TO UTILIZE ITS PATENTED X-RAY DETECTION TECHNIQUE AND ITS EXTENSIVE PATENTED AND PROPRIETARY DIGITAL DATA-HANDLING TECHNIQUES TO BUILD AN X-RAY MAMMOGRAPHIC IMAGING SYSTEM WHICH WILL PRODUCE DIAGNOSTIC IMAGES THAT MATCH OR EXCEED THE INFORMATION CONTENT OF EXISTING TECHNIQUES WITH A RADIATION BURDEN OF APPROXIMATELY 30 MR SKIN ENTRANCE EXPOSURE. THE SYSTEM WILLBE CAPABLE OF ...

MAJOR DRAWBACKS ASSOCIATED WITH IN VITRO ASSAYS FOR SENSITIVITY OF TUMORS TO SPECIFIC CHEMOTHERAPEUTIC DRUGS INCLUDE THE UNCERTAINTY OF END POINT VALIDITY, THE NEED FOR LARGE TISSUE SAMPLES, AND COST. FURTHERMORE, THESE ASSAYS DO NOT ADDRESS THE QUESTION OF CONVERSION OF THE DRUGTO ACTIVE MOITIES BY METABOLIC PATHWAYS IN THE HOST OR ALTERATION OF DRUG ACTIVITY BY BINDING TO PLASMA PROTEIN. ITIS PR ...

THE HIGH INCIDENCE OF BREAST CANCER IN WOMEN MAKES THIS DISEASE THE LEADING CANCER TYPE IN THIS POPULATION. THE PROPER STAGING OF THIS CANCER AND THE DETERMINATION OF THE PRESENCE OR ABSENCE OF ESTROGEN RECEPTORS PLAY MAJOR ROLES IN DETERMINING THE COURSE OF TREATMENT. PRESENTLY AVAILABLEMETHODS FOR SUCH STAGING AND ESTROGEN RECEPTOR IDENTIFICATION REQUIRE INVASIVE TECHNIQUES (SUCH AS SURGICALBIOP ...

THE PURPOSE OF THIS PROPOSAL IS TO DEVELOP A PROTOTYPE DEVICE FOR TRAINING COGNITIVELY OR PHYSICALLY IMPAIRED INDIVIDUALS IN VARIOUS SKILLS, USING AN INTERACTIVE SOFTWARE SYSTEM WITH A MICROCOMPUTER. IN ORDER TO MAXIMIZE THE UTILITY OF SUCH A DEVICE, INVESTIGATORS WILL FOCUS CONCENTRATION ON THREE TASKS. (1) THE INCORPORATION OF INPUT DEVICES, SUCH AS A TOUCH PLATE, ELECTRO-OCULOGRAPHY UNITS (DEVI ...

THE PROPOSED PROGRAM RELATES TO THE DEVELOPMENT OF A UNIVERSAL ONE-STEP APPROACH TO 1-CARBON-2-AMINO LABELING WITH ANY ISOTOPE OF CARBON OR NITROGEN INCLUDING STABLE ([13]C, [15]N), RADIO ([14]C), AND POSITRON-EMITTING NUCLIDES ([11]C, [13]N). GIVEN THE INCREASED INVOLVEMENT OF AMINO ACID TECHNOLOGY IN CANCER RESEARCH AND TREATMENT, THIS PROPOSAL IS PERTINENT TO THE DEVELOPMENT AND EVALUATIONOF SP ...