Award Data

This project will produce a method for constructing treatment plans with a guarantee on the quality of the solution. The plans produced by current techniques can fall short of the optimum or needlessly fail to satisfy constraints. As a result, the search for an improved solution is open-ended, exhausting hospital resources and manpower, and providing no assurance to patient or physician that a b ...

DESCRIPTION: (Adapted from Applicant's Abstract) Malaria is a disease which affects more than 300 million people each year and is fatal for 1.5 million. The overall objective of this STTR Phase I project is to produce a cGMP malaria vaccine consisting of the 42 kDa C-terminal polypeptide of P. falciparum merozoite surface protein-1 (MSP1.42) to be formulated with ...

DESCRIPTION: (Adapted from the Applicant's Abstract) Traumatic spinal cord injury (SCI) leads to permanent loss of motor function and control of function below the level of the injury. A significant portion of the loss is due to secondary factors rather than the initial trauma. These factors include increased extracellular concentrations of glutamate which ha ...

DESCRIPTION (provided by applicant): Cocaine abuse remains a grave concern for the American, and increasingly the world, population. As no current therapeutic agents are available to assist cocaine addicts in achieving and maintaining abstinence it is important that new pharmacotherapies be developed. One important question not usually addressed in the development ...

DESCRIPTION (adapted from applicant's abstract): The long-term goal of this project is to develop a rapid, safe, and sensitive test for the abnormal isofomms of prion (PrP/res) proteins associated with the transmissible spongifomm encephalopathies (TSE). The Surface Enhanced Raman Immunoassay (SERIA) assay to be evaluated will facilitate testing of sample ...

The aim of this project is to demonstrate feasibility of four different types of H. pylori assays. Assays will be developed for both the H. pylori organism and its antibody. The specific goal will be to develop a test which is rapid and very-low cost for screening of populations and for clinical laboratories. H. pylori is significant as a cancer risk as it can cause two types of malignancies: gast ...

DESCRIPTION (provided by applicant): The proposed research will develop two prototype analyzers, one of which will be interfaced with a perfusion probe for neurotransmitters, and their metabolites, Surface Enhanced Raman Assay (SERA) using Surface Enhanced Resonance Raman Scattering (SERRS). The first prototype will be placed in a translational researc ...

DESCRIPTION (provided by applicant): The proposed research will develop two prototype analyzers, one of which will be interfaced with a perfusion probe for neurotransmitters, and their metabolites, Surface Enhanced Raman Assay (SERA) using Surface Enhanced Resonance Raman Scattering (SERRS). The first prototype will be placed in a translational researc ...

Cermet, in collaboration with researchers at Georgia Institute of Technology, proposes to implement a lattice matched III-Nitride technology using existing substrates. The implementation of a lattice matched substrate promises to produce near dislocationfree III-Nitrides for the first time while the use of an existing substrate technology dramatically lowers development cost and reduces the devel ...

DESCRIPTION (provided by applicant): The current paradigm in therapeutic nuclear medicine is to optimize receptor binding molecules and then add on a moiety capable of carrying a radioisotope. This "afterthought" modification process results in suboptimum performance for such agents when dealing with molecules smaller than monoclo ...