Award Data

Obesity and its associated metabolic complications including diabetes are becoming increasingly prevalent in the general population as well as in military personnel. Brown adipose tissue (BAT) is a major site of energy expenditure through thermogenesis, which is mediated by the mitochondrial uncoupling protein-1 (UCP1). Studies in animals over the last 30 years as well as recent data in humans str ...

ABSTRACT: In order to significantly advance the fidelity and capability of current computational engineering tools, algorithms, techniques, and software which map effectively to emerging massively parallel hardware architectures must be developed. The objective of this project is to investigate and demonstrate specific techniques for enhancing the scalability of computational fluid dynamics (CFD) ...

ABSTRACT: The ability to oxidize organic functional groups in a selective manner is of major importance in preparing compounds of interest to the Air Force and DoD. This is particularly critical in the preparation of high energy density compounds and fuels. Heterocyclic ring systems that contain both nitro and amino groups have been found to be an important class of compounds that are useful in ...

Bioengineering offers an efficient and robust route for the production of enzymatic catalysts such as chloroperoxidase (CPO). The CPO from Caldariomyces fumago can catalyze non-specific halogenation of electrophilic organic molecules, epoxidation and hydroxylation of olefins and organic sulfides, and generation of free chlorine from chloride ion. The objectives are to: A. Develop a Caldari ...

The US Army has identified limitations of the DMFC (poor efficiency) and RMFC (complex system, high temperature process) approaches, and is soliciting innovation that will enable high efficiency hydrogen generation from methanol in a simple approach that has minimal thermal signature. It is the objective of this project to address these needs through the development of a novel hybrid electrochemic ...

Obtaining support from the local population is crucial for successful counterinsurgency (COIN) operations. US forces often fail to adequately understand the ethnographic characteristics of foreign populationswarfighters need access to ethnographic methods which help them to rapidly capture and interpret cultural, social, and economic data. A warfighter in high-risk areas needs easy-to-use tools th ...

ABSTRACT: The demonstration of 155 Kelvin refrigeration by optical cooling performed by the co-PIs of this proposal is a first step toward revolutionizing Air Force cryogenic systems. The stated focus of this STTR solicitation is"developing the concepts of a solid-state optical cryocooler that can approach 100 K with a cooling power exceeding 200 mW."To achieve this performance, a crucial propose ...

The amount of new malware encountered daily is accelerating at an unprecedented rate, an explosion that is also reflected in target and attack vector diversity. There has also been a dramatic increase in the use of malware kits, a problem in its own right because kits allow adversaries to easily create one-time-use malware variants for which generic signatures and general solutions are neither pra ...

ABSTRACT: Developing the quick strike capability of the Air Force requires hypersonic testing using advanced instrumentation to determine key aerodynamic parameters. A novel method for stand-off measurement of gas velocity is proposed. The method should operate over a wide dynamic range, from still air to hypersonic velocities. The method is non-contacting, precise, and spatially-resolved. It doe ...

The low cost chloroperoxidase can be potentially applicable to the inactivation of chemical agents due to its exceptional stability, broad substrate profile, and high catalytic efficiency. However, the high cost of producing large amounts of CPO is a major obstacle precluding the formulation and field deployment of this enzyme for chemical agent decontamination. Infoscitex Corporation (IST) and ...