Award Data

DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the development of a novel, bioactive polymer for use in ventricular assist devices (VAD), and other long-term blood contacting implantable devices. Although VADs are becoming an important therapeutic option for patients in heart failure, serious problems persist secondary to thromboembolic complications and continue t ...

DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the commercialization of a pediatric ventricular assist device (VAD). Although, VADs, both implantable and paracorporeal, have become an important surgical option for adult patients with myocardial failure unresponsive to less aggressive therapy, no VADs are commercially available for short-term use in children or smal ...

DESCRIPTION (provided by applicant): Physical models of proteins have been proven useful in science classrooms at the high school, undergraduate and graduate levels. These models become discovery tools in the hands of students, turning the abstract concepts of molecular structure and function into something real. Unfortunately, the current method of producing these models, by rapid prototyping in ...

DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. Although weight loss is the most effective treatment for type 2 diabetes, current methods for reducing weight typically are insufficient for long-term weight loss. The mission of AdipoGenix, Inc. is to discover, develop and license novel the ...

DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. Existing drug and dietary treatments for obesity are only modestly effective. An approach that is very likely to be effective in treating obesity and with a good side effect profile is a drug that acts directly on lipid metabolism in the fat ...

DESCRIPTION (provided by applicant): Combined gene therapy (Herpes Simplex Virus Thymidine Kinase + Anti-herpetic Prodrug) and radiation therapy (TKR therapy) is a novel approach in the armamentarium against cancer. This radio-gene therapy combination creates a new spatial co-operation whereby two local treatment modalities have demonstrated enhanced local and metastatic tumor control and prolong ...

This project will design and deliver a high accuracy monitor for the photo-chemically coupled pollutants nitric oxide, nitrogen dioxide and ozone using infrared absorption spectroscopy with quantum cascade (QC) lasers. The target molecules are monitored at air quality stations worldwide using instruments which require frequent calibration and are subject to significant chemical interferences (in t ...

This project will design and deliver a high accuracy monitor for the photo-chemically coupled pollutants nitric oxide, nitrogen dioxide and ozone using infrared absorption spectroscopy with quantum cascade (QC) lasers. The target molecules are monitored at air quality stations worldwide using instruments which require frequent calibration and are subject to significant chemical interferences (in t ...

DESCRIPTION (provided by applicant): The Quartz Crystal Microbalance (QCM) is a well-established technology for quantifying small changes in mass. The long-term objective of this program is to improve the QCM so that it is suitable for use as a field test for the common, foodborne bacteria. To do this, we will modify the standard quartz crystal (QC) used in the QCM so as to increase its background ...

(Revised Abstract) Description: The ascertainment of millions of SNPs in the human genome, characterization of haplotype blocks and development of improved SNP-based linkage panels has fueled the need for accurate, efficient, and low cost SNP genotyping technologies to support genetic inheritance and disease association studies. The overall goals of this proposal are to develop and test a novel m ...