Award Data

DESCRIPTION (provided by applicant): The ultimate objective of this proposed program is the commercialization of a neonate ventricular assist device (VAD). Although VADs, both implantable and paracorporeal, have become an important surgical option for adult patients with myocardial failure unresponsive to less aggressive therapy, no VADs are commercially available for short-term use in small infan ...

DESCRIPTION (provided by applicant): This Phase I proposal seeks support to evaluate the feasibility of developing an extracellular matrix (ECM) biologic scaffold as a repair device for atrial septal defects (ASD). ASDs are one of the most common forms of congenital heart disease and account for approximately 30-40% of all congenital heart defects seen in adults. Closure of an ASD can be performed ...

The future of nuclear fusion relies in part on the development of effective plasma facing components (PFCs) that can withstand the intense heat loads, forces, and neutron bombardment of long-pulse, high-power reactor operation. Current PFC designs for the next-generation International Thermonuclear Experimental Reactor (ITER), which will require thousands of PFCs, involve beryllium (Be) armor bon ...

Solid oxide fuel cells (SOFCs) are one of the most efficient and cleanest power generating systems under development. A key component in the SOFC generator is the cathode-air heat exchanger or recuperator, which ensures that the cathode air (and, thereby, the cells) is at a sufficient temperature to permit ion mobility and improve overall SOFC system efficiency by reducing stack losses. However, ...

DESCRIPTION (provided by applicant): The ability to culture human embryonic stem cells generated a great deal of excitement about their vast potential for treating a variety of human diseases such as diabetes, heart disease, neurological, retinal and skin disorders to name a few. Unlike adult stem cells, embryonic stem cells have indefinite growth potential and the potential to develop into any t ...

Nanofiber nonwoven spunbonded materials technology is adapted for use in a personnel lowering device. The resulting device will be simple, easy to use, and relatively low cost.

Advanced Diamond Solutions, Inc. proposes the development of a novel high efficiency solar cell design based on amorphous diamond nanotip thermoelectric power generation properties. Amorphous diamond has a unique set of material characteristics stemming from its combination of graphitic, diamond and carbon-nanotube structures. Amorphous diamond inherently possesses numerous discrete energy state ...

DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures or proteins of interest per organism. Crystallization and X-ray diffraction of these proteins is routinely performed to determine their 3D structure which needs to be ...

DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and subsequent volume transfused. In neonatal infants, there may not be enough collected blood sample to perfo ...

Advanced Liquid Logic proposes to develop a very capable analyzer based on its digital microfluidic technology. Such an analyzer would be:  Capable of both simple and complex biological assays  Small, lightweight, power efficient, and easy to operate  Fully programmable and remotely reprogrammable Under NIH funding we have demonstrated clinical chemistry blood diagnostic testing on our ...