Award Data

DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the development of a novel, bioactive polymer for use in ventricular assist devices (VAD), and other long-term blood contacting implantable devices. Although VADs are becoming an important therapeutic option for patients in heart failure, serious problems persist secondary to thromboembolic complications and continue t ...

DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the commercialization of a pediatric ventricular assist device (VAD). Although, VADs, both implantable and paracorporeal, have become an important surgical option for adult patients with myocardial failure unresponsive to less aggressive therapy, no VADs are commercially available for short-term use in children or smal ...

72905S03-I High speed networks will be required to deliver the large data volumes associated with DOE science experiments. Deployment scenarios for 10 Gb/s enterprise and access networks will require optical interfaces capable of spanning distances from 100 m to 10 km. Presently available 10 Gb/s optical front-ends are not generally applicable because they are either lacking in capability or ar ...

This SBIR Phase II research project strives to develop an Advanced Ultrasonic Beamformer that is unparalleled in its scalability and signal processing features. The ultrasonic beamformer architecture will be unique in its breadth of features. The architecture was developed as the superset of features across several fields including medical imaging, medical therapy, bone density measurement, vascul ...

In the high noise environment of fixed and rotary wing aircraft used for casualty evacuation, a critical need exists to detect normal vs. pathologic heart and breath sounds and discriminate among their components. Evaluations by the Army staff at theU.S. Army Aeromedical Research Laboratory has demonstrated that no such capability exists whether in standard acoustic stethoscopes or electronic no ...

Active Signal Technologies proposes a thoroughly planned systematic development effort to produce a system that will meet the requirements of rugged operational monitoring to provide continuous electrocardiogram (ECG) and ventilation data on activelydeployed personnel. The program starts with a comprehensive literature survey across a broad range of life sciences, technology and government resear ...

DESCRIPTION (provided by applicant): With over 1.5 million persons suffering head injury annually in the U.S., and approximately 50,000 dying from these injuries, a need exists for early direct assessment of brain injury. Currently, injuries must be inferred from Glascow Coma Scores (GCS), low blood pressure, and/or low pulse oximetry, but there is no direct method of measuring brain condition at ...

The objectives of this research are to fully design and develop a prototype of an environmental impact assessment and mitigation software suite, focusing on the impact of active acoustic emissions on marine mammals. This software will be: web-enabled,cross-platform capable, and be applicable throughout the life cycle of active source programs. Databases of biological data, environmental regulat ...

Even when built to exacting standards, towed arrays invariably suffer acoustic sensor failures. A relatively small number of sensors can have large negative impact on beamformer side-lobe levels. This SBIR program will develop, implement, and integrate atowed array beamformer shading algorithm that provides robust performance as hydrophones fail. The selected algorithm must provide better acoust ...

DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. Although weight loss is the most effective treatment for type 2 diabetes, current methods for reducing weight typically are insufficient for long-term weight loss. The mission of AdipoGenix, Inc. is to discover, develop and license novel the ...