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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Cannula System for "Bridge to Recovery" Cardiac Assist

    SBC: ABIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Cardiac failure is the, largest single cause of mortality in the United States today. With an increase in the use of long-term cardiac assist devices, there is also a need for the short-term "bridge to recovery" application. This application is intended to provide a low-cost temporary support for patients whose heart is capable of recovering. This "patient scr ...

    SBIR Phase I 2005 Department of Health and Human Services
  2. Enzymatic Pleurodesis for Malignant Pleural Effusions

    SBC: AERIS THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase I SBIR application is presented by Aeris Therapeutics, Inc. of Woburn, MA. It will examine the feasibility of using a novel enzyme based-system to produce safe, clinically-effective pleurodesis for treatment of malignant pleural effusions. Preliminary data, summarized in this application, suggest that an enzymatic system has the potential for bei ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Breath Analysis using Quantum Cascade Lasers

    SBC: Aerodyne Research, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The analysis of components in human breath is a powerful non-invasive technique for the diagnosis and monitoring of asthma, cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The presence of elevated levels of nitric oxide (NO), carbon monoxide (CO), and ethane (C2H6) in the breath have been identified as biomarkers of these diseases, wh ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. In Vivo Molecular Imaging of Cancer in Small Animals

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Murine models of cancer now have an essential role in formulating modern concepts of carcinogenesis and metastasis, and provide us with a realistic means of developing and evaluating new diagnostic and therapeutic techniques. Moreover, transgenic and knock-out techniques for manipulating the genome allow us to tailor animal models that accurately recapitulate ...

    SBIR Phase II 2005 Department of Health and Human Services
  5. High Resolution Small Animal SPECT

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Phase I: SPECT is non-invasive imaging technique which provides an image of the three dimensional distribution of radionuclide in any slice through an organ under study. These images allow investigation of metabolism in the region being studied and are a useful tool for diagnosing symptoms of diseases such as cancer and myocardial ischemia. SPECT is also showin ...

    SBIR Phase II 2005 Department of Health and Human Services
  6. High Sensitivity X-ray Detector for PET/CT

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Dramatic advances in imaging technology, especially for small-animal imaging, have been an important driving force in establishing the field of molecular and genomic imaging. One of these new technologies, microPET, has demonstrated a tremendous potential in the study of small animal models, allowing the measurement of biological parameters and permitting i ...

    SBIR Phase II 2005 Department of Health and Human Services
  7. A Fast, High Luminosity Scintillator for PET

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a nuclear imaging modality that makes use of a range of positron-emitting tracers to provide images that reflect different parameters relevant to tumor biology. Tumor cells generally differ from normal cells in many respects, including rates of glucose utilization, proliferation and protein synthesis. PET tracers such as ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Digital Fluoroscopy for Cardiac Imaging

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Real-time or dynamic radiographic imaging (fluoroscopy) provides vital information concerning internal organ structure, flow of contrast agents and in-vivo instrument positioning. Fluoroscopy is a very important modality for cardiac and vascular imaging including subtraction angiography where it is used for locating and evaluating cardiac structures, major v ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Direct Conversion Dental Sensor

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Radiation Monitoring Devices (RMD) proposes to develop a new dental x-ray imager that will have all the advantages of a digital technology and retain the most desirable aspects of image quality that film emulsions provide. The device will be a blend of two technologies - silicon based imaging arrays and semiconductor x-ray conversion layers. RMD will work on ta ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Digital 2-D Neutron Detector for Protein Function Sudies

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Information on the structure and function of proteins is important for unveiling the biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, however is not well suited for analyzing hydrogen atoms and water molecules. It has been shown that the thermal neutrons are a far better tool for ...

    SBIR Phase I 2005 Department of Health and Human Services

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