Award Data

DESCRIPTION (provided by applicant): The main objective of this project is to develop a new therapeutic to improve the outcome for patients with intermediate-risk prostate cancer. The indication is a first-line adjuvant to be combined with radiation therapy for prostate cancer. The desired outcomes are improved local control rate, decreased recurrence and improved disease-free survival. This grant ...

DESCRIPTION (provided by applicant): The overall goal of this project is to develop broad-spectrum antibiotics against Yersinia pestis and other important human pathogens. The potential use of engineered, multi-drug-resistant strains as agents of bioterrorism necessitates the development of new anti-Y. pestis therapies. This is a challenging goal, since the last novel class of broad-spectrum antib ...

Many airborne vehicles require thick polymeric coatings on complex, concave and convex surfaces, which may be metallic, composite, or ceramic. The common method for applying these coatings involves spraying many individual layers, and allowing solvent flash and drying between each layer. A coating which is built up to 0.250” thickness, may require more than 100 layers of sprayed on coatings. Thi ...

During Phase I, we experimented with several transition approaches and ran into three hurdles: 1) No matter how good the method for transitioning technology, if the development process has not been well-managed, there will be no technology to transition; 2) Transition does not happen without an incredible amount of expertise and data; 3) Good technology does not matter if no one is aware of its e ...

DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a bioterrorist threat. With the best current therapies, lethality is typically as high as 40%. The overall goal of this proposal is the development of new drugs against this organism. In Phase I, the high sequence similarity between 8. pseudomallei and its less virulent relative Pseudomonas aeruginosa was exploited to build innovati ...

Chiliad's Phase II effort will implement and test enhancements and extensions of automated metadata generation capabilities designed in Phase I, and the tight integration of those capabilities with other software systems and applications. Some of the results of Chiliad’s SBIR funded efforts have already been deployed in operational production systems across the FBI, within new releases of the Bu ...

DESCRIPTION (provided by applicant): Heart failure (HF) represents an enormous clinical problem demanding effective therapeutic approaches. Despite advances in traditional approaches to its treatment, including pharmacological management, myocardial revascularization, mechanical assist devices, and transplantation, heart failure remains a leading cause of death worldwide. Therefore, a novel therap ...

DESCRIPTION (provided by applicant): This application is a resubmission in response to AA-04-002 from the National Institute on Alcohol Abuse and Alcoholism to continue our STTR (Phase I and II) study on the development of NPI-031G (Puerarin), an Isoflavone-C-glycoside isolated from Puerira lobota (Kudzu), as a botanical anti-craving agent for the treatment of alcohol drinking problems. In STTR ...

DESCRIPTION (provided by applicant): The goal of this project is to discover novel broad-spectrum antibiotics acting against critically important human pathogens. The unmet need is especially acute for Gram negative pathogens, where we are rapidly running out of options for treating multidrug resistant species of Pseudomonas, Acinetobacter, Burkholderia, Klebsiella and Enterobacter. This is a chal ...

DESCRIPTION (provided by applicant): Following a major bioterrorism attack or infectious disease outbreak, millions of potential victims may require rapid testing to ensure delivery of life-saving therapeutic treatment to those who need it. Because today there is no diagnostic method capable of high-performance large-scale testing in a crisis situation, thousands could die needlessly due to ineffi ...