Award Data

DESCRIPTION (provided by applicant): The overall goal of this project is to develop broad-spectrum antibiotics against Yersinia pestis and other important human pathogens. The potential use of engineered, multi-drug-resistant strains as agents of bioterrorism necessitates the development of new anti-Y. pestis therapies. This is a challenging goal, since the last novel class of broad-spectrum antib ...

During Phase I, we experimented with several transition approaches and ran into three hurdles: 1) No matter how good the method for transitioning technology, if the development process has not been well-managed, there will be no technology to transition; 2) Transition does not happen without an incredible amount of expertise and data; 3) Good technology does not matter if no one is aware of its e ...

DESCRIPTION provided by applicant In this Phase II project development and clinical validation of an ELISA test for in vitro diagnosis of Babesia microti infection will be completed Babesiosis is an emerging tick borne parasitic disease which may cause severe to fatal illness in immunocompromised or otherwise weakened patients and may be carried in the blood subclinically in up to of the ...

DESCRIPTION provided by applicant Human babesiosis is a malaria like illness caused by infection of red blood cells by the protozoan parasite Babesia microti or related species primarily transmitted to humans through the bite of infected deer ticks Babesiosis can also be transmitted by blood transfusion and is currently acknowledged as the foremost unaddressed infectious risk to the US blood ...

DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a bioterrorist threat. With the best current therapies, lethality is typically as high as 40%. The overall goal of this proposal is the development of new drugs against this organism. In Phase I, the high sequence similarity between 8. pseudomallei and its less virulent relative Pseudomonas aeruginosa was exploited to build innovati ...

Chiliad's Phase II effort will implement and test enhancements and extensions of automated metadata generation capabilities designed in Phase I, and the tight integration of those capabilities with other software systems and applications. Some of the results of Chiliad’s SBIR funded efforts have already been deployed in operational production systems across the FBI, within new releases of the Bu ...

DESCRIPTION (provided by applicant): Heart failure (HF) represents an enormous clinical problem demanding effective therapeutic approaches. Despite advances in traditional approaches to its treatment, including pharmacological management, myocardial revascularization, mechanical assist devices, and transplantation, heart failure remains a leading cause of death worldwide. Therefore, a novel therap ...

Not Available

DESCRIPTION provided by applicant The goal of the project is to develop a therapeutic capable of sterilizing recalcitrant chronic infections such as deep seated abscess osteomyelitis endocarditis and biofilms of indwelling devices Many of these infections are essentially untreatable and lead to substantial morbidity and mortality In many cases recalcitrance of an infection is not caused b ...

Boston Engineerings proposed project significantly increases the Navys capabilities by providing a technology that performs superbly in tactically critical littoral and VSW applications currently unaddressed. We propose to advance the existing technology readiness level (TRL) by combining our GhostSwimmer AUV with actuation, sensing, payload, and processing technology as applicable. Our proposed p ...