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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. 3D Imaging Flow Cytometer

    SBC: NanoCellect Biomedical, Inc.            Topic: NIDA

    D Imaging Flow Cytometer NanoCellect BiomedicalIncRESEARCH andampRELATED Other Project InformationPROJECT SUMMARY Fluorescence activated cell sortingFACSor flow cytometry enables clinicians and researchers to quantitatively characterize the physicalcell sizeshapegranularityand biochemicalDNA contentcell cycle distributioncell surface markersand viabilityproperties of cellshowever FACS devices do n ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Bioactive Nanofibrous Sewing Cuff for Treatment of Cardiac Valvular Disease

    SBC: BIOSURFACES, INC.            Topic: NHLBI

    PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. A Biological Small Angle X-ray Scattering Station (BioSAXS) for the Compact Light


    7. Project Summary/Abstract We propose to develop a Biological Small-angle X-ray Scattering (BioSAXS) station for the Compact Light Source, a powerful new generation of X-ray sources, which will enable biologists and biochemists to pursue state-of-the-artresearch in macromolecular structure studies in their own laboratories. The frontier of structural biology is the determination of large macromol ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. A Cell-Penetrating Anthrax Antitoxin


    DESCRIPTION (provided by applicant): The goal of this research is to develop an economical, safe, effective therapy to reverse the activity of the catalytic component, LF, of the Bacillus anthracis toxin (lethal toxin), within the cytoplasm of the intoxicated cell. Success in achieving this goal will lead to better outcomes than currently seen with antibiotics or antitoxins like raxibacumab or PB ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. A Circulating Biomarker for use in Monitoring Metastatic Breast Cancer

    SBC: A&G PHARMACEUTICAL, INC.            Topic: NCI

    Cost effective and minimally invasive monitoring of metastatic breast cancerMBCpatients for disease progression or response to therapy is an unmet need in the clinical management of the diseaseImaging technologies are currently the gold standard of such monitoringHoweverthere is controversy regarding the type andampfrequency of imaging requiredImaging is expensivetime consumingslow to detect disea ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. A Combination Therapy Approach to Treating Drug Resistant Fungal Infections

    SBC: Amplyx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Despite the introduction of newer triazoles and echinocandins invasive fungal infections IFIandapos s including invasive candidiasis IC remain very difficult to treat with currently available antifungals The annual cost burden of treating nosocomial fungal infections exceeds $ billion a year in the United States alone Worldwide the annual incidence o ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. A Compact Hybrid Magnet with High Homogeneity for X-Band DNP/NMR and EPR Spectroscopy

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 400

    Project SummaryAbstract We propose to develop aT compact and portable hybrid magnet with high homogeneityandltppmandT of sweep rangeThe magnet system will be used in Overhauser Dynamic Nuclear Polarization experiments in the X Band for studying water dynamics in molecules and other analytical chemistry applicationsIn Phase Iwe will designbuild and test a prototype magnet to meet the above stated r ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A Compact, High-power Terahertz Amplifier for DNP-NMR and EPR Spectroscopy

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): We propose to develop a compact, cost-effective Traveling Wave Tube (TWT) amplifier at 263 GHz with 50 W of peak power, 5 W of continuous wave power and 5% instantaneous bandwidth for application in Dynamic Nuclear Polarization (DNP) enhanced solid-state and solution-state NMR and Electron Paramagnetic Resonance (EPR) spectroscopy. With DNP, the inherently smal ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. A Comprehensive Fall Prevention System for Memory Care: Final Feasibility and Randomized Controlled Study

    SBC: SAFELYYOU INC.            Topic: NIA

    Abstract In the USAlzheimer s diseaseADis the single most expensive diseasethe only disease in the top six for which the number of deaths is increasingThe greatest cost contributors are frequent hospitalizationswhere falls are the largest culpritand frequent need for assistance with the activities of daily livingFall safety systems show the potential to reduce costs and increase quality of care by ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A computational approach to early sepsis detection

    SBC: DASCENA            Topic: NCATS

    Abstract SignificanceIn this SBIR projectwe propose to improve the performance of InSighta machine learningbased sepsis screening systemin situations of limited training data from the target clinical siteThe proposed work will make possible prospective clinical deployments to sites which are smaller or lack clinical data repositoriesby significantly reducing the amount of training data necessary d ...

    SBIR Phase I 2018 Department of Health and Human Services

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