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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Combination Therapy Approach to Treating Drug Resistant Fungal Infections

    SBC: Amplyx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Despite the introduction of newer triazoles and echinocandins invasive fungal infections IFIandapos s including invasive candidiasis IC remain very difficult to treat with currently available antifungals The annual cost burden of treating nosocomial fungal infections exceeds $ billion a year in the United States alone Worldwide the annual incidence o ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A Computer Modeling Approach

    SBC: Amplyx Pharmaceuticals, Inc.            Topic: 101

    DESCRIPTION Cryptococcal meningitis CM continues to be a significant cause of mortality among HIV positive individuals and a major worldwide health concern The estimated mortality rate for HIV infected acute CM patients is within months after infection in North America despite patient access to good health care resources In sub Saharan Africa alone the effects of CM are devastating ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A human monoclonal for RSV prophylaxis

    SBC: MAPP BIOPHARMACEUTICAL, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Respiratory syncytial virus RSV is the leading cause of lower respiratory tract illness in infants and young children worldwide In premature neonates RSV infection results in high levels of morbidity and mortality In the United States alone there are more than hospitalizations and deaths per year attributable to RSV The only prophylaxis for R ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. A molecular barcoding sequencing kit for highly efficient and accurate single cel

    SBC: CELLULAR RESEARCH, INC.            Topic: 172

    DESCRIPTION provided by applicant We propose to develop and commercialize high sensitivity and accuracy RNA sequencing kits suitable for gene expression measurements in limiting input samples such as single cells During Phase I we proposed the concept of using molecular barcodes in the form of DNA sequence tags to label individual molecules or copies of RNA for gene expression analysis in ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. A molecularly targeted pre- and post-exposure vaccine for anthrax

    SBC: VLP BIOTECH, INC.            Topic: NIAID

    DESCRIPTION provided by applicant We have shown that immunization of rabbits with multiple antigenic peptides MAPs displaying sequence from domain of protective antigen PA elicit antibodies specific for a linear determinant within the loop of PA that mediate potent neutralization of lethal toxin LeTx in vitro We have now shown in two separate large studies that antibodies aga ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. A MULTIPLEXED REMOTE SYSTEM FOR FILOVIRUS DISEASE SURVEILLANCE

    SBC: Cellmic, LLC            Topic: NIAID

    Proposes an advanced Ebola and Marburg disease telemonitoring and assessment platform that will enable the digital modernization of point of care diagnosticsdisease surveillanceand healthcare screening by minimally trained personnel at the point of careOffering a complete diagnostics solutionthe platform includes a microfluidics assay for the detection of infections caused by Ebola and Marburg fil ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. A Music-Based Rehabilitation Device for Training and Assessing Hand Function

    SBC: FLINT REHABILITATION DEVICES, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Hand impairment is a common condition that contributes substantially to disability in the U S and around the world In the case of stroke alone it is estimated that of the individuals who survive a stroke each year require hand therapy Intensive rehabilitation exercise reduces long term hand impairment Unfortunately as soon as weeks after th ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. A Patient-Driven Rehabilitation System to Improve Upper Limb Amputee Outcomes

    SBC: Infinite Biomedical Technologies, LLC            Topic: NICHD

    DESCRIPTION provided by applicant A patient driven rehabilitation system to improve upper limb amputee outcomes The goal of our research program is to develop technological solutions that restore function for upper extremity amputees For these individuals one of the most promising developments in the past decade has been the introduction of fully dexterous terminal devices However an effe ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. A Rewards Program Contributing to Healthier Eating in Restaurants & Schools

    SBC: ACCENTS ON HEALTH, INC.            Topic: 102

    DESCRIPTION provided by applicant This research will expand implement and evaluate a restaurant based incentive program that provides funding to schools to support school Wellness Initiatives such as physical activity nutrition education and healthier lunch programs while encouraging and rewarding healthy eating behaviors in restaurants at the same time This project represents the first s ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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