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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Serum Hepcidin Immunoassay: Laboratory to Marketplace

    SBC: INTRINSIC LIFESCIENCES LLC            Topic: 300

    DESCRIPTION provided by applicant Disorders of iron metabolism are among the most common human diseases During the last decade rapid progress has been made in understanding the molecular basis of iron homeostasis and its disorders The peptide hormone hepcidin has emerged as the master regulator of iron metabolism Dysregulation of hepcidin is the principal or contributing factor in most syst ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. SBIR TOPIC 096:Novel Biodegradable Stents for Neonatal Aortic Coarctation

    SBC: 480 Biomedical Inc.            Topic: NHLBI

    Aortic coarctation is a common congenital heart condition that is usually recognized during the neonatal period early after birth The usual treatment is open surgery Non surgical catheter based stent therapy is not available to treat neonatal aortic coarctation because children outgrow commercially available metallic stents Absorbable stents might revolutionize the treatment of aortic coarctation ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. The purpose of this contract is to develop an assay to detect minor populations of resistant variants in blood specimens from HIV-infected individuals with HIV RNA viral loads above 1000 copies/ml

    SBC: ALDATU BIOSCIENCES, INC.            Topic: NIAID

    Antiretroviral therapyARTreduces mortality and morbidity in HIV infected individualsbut specific HIV mutationsDRMsare associated with resistanceIt is now known that certain DRMs can contribute to virological failure even at very low concentrationsbut standard tests are inadequately sensitive to detect these minor variantsMethods to detect minor variants that contribute to HIV virological failure a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Delivery of passive immunity against HIV using commensal vaginal Lactobacillus bioengineered to secrete broadly neutralizing domain antibodies

    SBC: OSEL, INC.            Topic: NIAID

    DESCRIPTION Women bear the brunt of the global AIDS epidemic due in part to their inherent social and biological vulnerability Biologically the cervical and vaginal mucosae are vulnerable targets for HIV transmission In healthy women of childbearing age mucosal antibodies and microbiota including Lactobacillus jensenii help protect these surfaces and serve to block the colonization and infe ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 349: Quantum Dot FRET Immunoassay to Quantify Intramolecular Epitopes of Analytes in Tissue Sections

    SBC: Ocean Nano Tech LLC            Topic: NCI

    This proposal is to develop a novel slide based proximity assay platform to quantify protein phosphorylation on tissues. The novelty of this assay platform is derived from the use of the quantum dot with two emission peaks for fluorescence resonance energy transfer (FRET): one emission as internal standard and the other as FRET donor. Change of ratio of the two emission intensity during the FRET c ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic 345: RadTox- Measuring Radiation Toxicity using Circulating DNA

    SBC: DiaCarta, Inc.            Topic: NCI

    The QuantiDNA RadTox System is a unique, patented technology that measures tissue damage shortly following injury using cell-free DNA from a drop of blood. Premised on murine and primate studies showing circulating DNA is logarithmically increased with whole-body radiation dose, RadTox has the potential to overcome many of the species-specific challenges faced by biomarker panels. The phase I SBIR ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Clinical Evaluation of a Long Term Implanted Glucose Sensor

    SBC: GLYSENS, INC.            Topic: 200

    DESCRIPTION provided by applicant Diabetes is a major healthcare problem that is reaching crisis proportions and new therapies are urgently needed We have developed a long term fully self contained glucose monitoring sensor with battery operated telemetry for implantation in subcutaneous tissues The sensor would have unique applications in type diabetes for hypoglycemia warning insulin d ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Portable Gas Perfusion System for Pancreas Preservation

    SBC: Giner, Inc.            Topic: 200

    DESCRIPTION provided by applicant Pancreatic islet transplantation ITx is an emerging treatment for a subset of Type diabetics for which standard insulin therapies are insufficient I is a promising alternative to pancreas transplantation since ITx has significantly less surgical risk and a less toxic immunosuppression regimen Enhanced organ preservation via the proposed technology has th ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Dendritic Cell-Targeted HIV Vaccine Product

    SBC: AVANT IMMUNOTHERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION This proposal is a unique collaboration between a small but full capability biotechnology company and a premier academic institution and laboratory to develop a novel product for clinical trials to prevent HIV infection This proposal describes a vaccine product aimed to provide a feasible and nontoxic way to elicit strong immunity in humans to HIV proteins and it will provide an ad ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Optimization of Arenavirus Antivirals

    SBC: Arisan Therapeutics, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Seven distinct arenavirus species have been associated with arenaviral hemorrhagic fevers AVHF in humans with case fatality rates as high as Human infection with arenaviruses typically occurs through contact with materials contaminated with the excretions of an infected rodent although direct human to human transmission often occurs in clinical settings ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health

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