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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Optimization of Arenavirus Antivirals

    SBC: Arisan Therapeutics, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Seven distinct arenavirus species have been associated with arenaviral hemorrhagic fevers AVHF in humans with case fatality rates as high as Human infection with arenaviruses typically occurs through contact with materials contaminated with the excretions of an infected rodent although direct human to human transmission often occurs in clinical settings ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Digitally Blending HIV Prevention for Heightened Impact

    SBC: DFusion            Topic: 105

    DESCRIPTION provided by applicant Young people remain disproportionately affected by HIV School based prevention programs such as Reducing the Risk RTR have demonstrated effectiveness in reducing the sexual risk taking behaviors associated with HIV transmission School settings are an important venue for reaching adolescents nationwide with effective prevention education and most states h ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Automated Ultrasensitive Detection of Light Chain Restriction in Lymphoproliferat

    SBC: ADVANCED CELL DIAGNOSTICS, INC.            Topic: 102

    DESCRIPTION provided by applicant Immunoglobulin Ig light chain restriction LCR detection is an important molecular diagnostic tool in the differential diagnosis that includes lymphoid hyperplasia atypical lymphoid hyperplasia chronic inflammation and B cell neoplasms LCR can be detected by flow cytometry FCM as an abnormal kappa lambda ratio on the cell surface However FCM require ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Portable Gas Perfusion System for Pancreas Preservation

    SBC: Giner, Inc.            Topic: 200

    DESCRIPTION provided by applicant Pancreatic islet transplantation ITx is an emerging treatment for a subset of Type diabetics for which standard insulin therapies are insufficient I is a promising alternative to pancreas transplantation since ITx has significantly less surgical risk and a less toxic immunosuppression regimen Enhanced organ preservation via the proposed technology has th ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Accelerating Wound Healing through RNAi

    SBC: Somagenics, Inc.            Topic: 300

    DESCRIPTION provided by applicant The growing populations of the elderly and those with type II diabetes are at high risk for developing chronic wounds that are slow to heal Effective therapeutics to promote wound healing could significantly improve the lives of these people Normal wound healing involves a coordinated cascade of events that are stimulated in part by the hypoxia that results f ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Real-time Point of Care Insulin Monitoring Device for Improved Diabetes Managemen

    SBC: Aptitude Medical Systems, Inc.            Topic: 200

    DESCRIPTION provided by applicant In the United States million children and adults have diabetes and million have pre diabetes Insulin therapy is critical in Type Diabetes and now understood to be an inevitable therapeutic component for Type Diabetes in order to achieve adequate glycemic control However none of the available commercial insulin preparations are able to simulate n ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. An intervention to improve adolescent headache self-management

    SBC: Inflexxion, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant A mobile based intervention to improve adolescentsandapos headache self management Abstract Headache pain is a common and significant problem for adolescents King et al As headaches become more frequent and severe the negative impact on happiness increases and adolescents report less satisfaction with their health and with their life Sillampaa ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Fluorescence Lifetime Dynamics to Understand Brain Neural Activities and Behavior

    SBC: ChiSquare Bioimaging, LLC            Topic: 500

    DESCRIPTION provided by applicant The overall objective of the proposed project is to create a compact robust and easy to use device that is capable of sensitive and quantitative detection of fluorescence lifetime indicators of physiological and biochemical dynamics deep in the brain of a freely moving mouse In contrast to fluorescence intensity based methods fluorescence lifetime can delin ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. An Open Source Precision Medicine Platform for Cloud Operating Systems

    SBC: CUROVERSE, INC.            Topic: 400

    DESCRIPTION provided by applicant Rapid improvements in DNA sequencing and synthesis have the potential to usher in a new era of precision medicine To realize this vision however we must re imagine the computational and storage infrastructure used to manage and extract actionable results from the massive data sets made possible by widely available advances in DNA sequencing and synthetic bio ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Clinical Evaluation of a Long Term Implanted Glucose Sensor

    SBC: GLYSENS, INC.            Topic: 200

    DESCRIPTION provided by applicant Diabetes is a major healthcare problem that is reaching crisis proportions and new therapies are urgently needed We have developed a long term fully self contained glucose monitoring sensor with battery operated telemetry for implantation in subcutaneous tissues The sensor would have unique applications in type diabetes for hypoglycemia warning insulin d ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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