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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Serum Hepcidin Immunoassay: Laboratory to Marketplace

    SBC: INTRINSIC LIFESCIENCES LLC            Topic: 300

    DESCRIPTION provided by applicant Disorders of iron metabolism are among the most common human diseases During the last decade rapid progress has been made in understanding the molecular basis of iron homeostasis and its disorders The peptide hormone hepcidin has emerged as the master regulator of iron metabolism Dysregulation of hepcidin is the principal or contributing factor in most syst ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. DMX: Enabling Blind Source Separation for Hearing Health Care

    SBC: SPEECH TECHNOLOGY/APPLIED RESEARCH CORP.            Topic: NIDCD

    DESCRIPTION provided by applicant Typical biological environments comprise complex mixtures of signals from multiple biological and environmental sources Some sources contain critical information that researchers seek to acquire other sources are distractions that interfer with data acquisition Common acoustic environments are an important example a significant segment of the aging US popul ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Real-time Point of Care Insulin Monitoring Device for Improved Diabetes Managemen

    SBC: Aptitude Medical Systems, Inc.            Topic: 200

    DESCRIPTION provided by applicant In the United States million children and adults have diabetes and million have pre diabetes Insulin therapy is critical in Type Diabetes and now understood to be an inevitable therapeutic component for Type Diabetes in order to achieve adequate glycemic control However none of the available commercial insulin preparations are able to simulate n ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Clinical Evaluation of a Long Term Implanted Glucose Sensor

    SBC: GLYSENS, INC.            Topic: 200

    DESCRIPTION provided by applicant Diabetes is a major healthcare problem that is reaching crisis proportions and new therapies are urgently needed We have developed a long term fully self contained glucose monitoring sensor with battery operated telemetry for implantation in subcutaneous tissues The sensor would have unique applications in type diabetes for hypoglycemia warning insulin d ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Efficient double hybrid density functional theory algorithms for conformational a

    SBC: Q-CHEM, INC.            Topic: 400

    DESCRIPTION provided by applicant Q Chem is a state of the art commercial computational quantum chemistry program that has aided tens of thousands users in their modeling of molecular processes in a wide range of disciplines including biology chemistry and materials science In quantum chemistry density functional theory DFT and second order Moller Plesset theory MP are already heavil ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Multiplexed Nucleic Acid Assays

    SBC: PROGNOSYS BIOSCIENCES, INC.            Topic: 100

    DESCRIPTION provided by applicant New technologies are needed to enable the multiplexed analysis of gene expression in many samples in parallel This would enable the generation of high resolution maps of gene expression of the mammalian brain as well as other complex tissues This proposal aims to develop novel technology to enable applications of this type It is suited to analyzing complex ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Accelerating Wound Healing through RNAi

    SBC: Somagenics, Inc.            Topic: 300

    DESCRIPTION provided by applicant The growing populations of the elderly and those with type II diabetes are at high risk for developing chronic wounds that are slow to heal Effective therapeutics to promote wound healing could significantly improve the lives of these people Normal wound healing involves a coordinated cascade of events that are stimulated in part by the hypoxia that results f ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. The Development of RORgt Immunomodulators Targeting the TH17 Axis in IBD- Phase 2

    SBC: VISIONARY PHARMACEUTICALS, INC.            Topic: 300

    DESCRIPTION provided by applicant In our SBIR Phase research program we discovered two novel ROR t inverse agonist lead series and showed efficacy in two animal models of inflammatory bowel disease IBD IBD is a significant health burden reducing the quality of life of million people in the United States alone Th cells are a lineage of T helper cells that have recently been identifie ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. An Integrated THz System for DNP-enhanced NMR Spectroscopy

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 100

    DESCRIPTION provided by applicant The proposed research focuses on the development of a DNP NMR system for Dynamic Nuclear Polarization DNP enhanced solid state NMR spectroscopy at MHz High resolution structures are essential to the understanding of the complex functions of bio macromolecules and NMR spectroscopy is a major source for such information However the method suffers from an ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Digitally Blending HIV Prevention for Heightened Impact

    SBC: DFUSION INC.            Topic: 105

    DESCRIPTION provided by applicant Young people remain disproportionately affected by HIV School based prevention programs such as Reducing the Risk RTR have demonstrated effectiveness in reducing the sexual risk taking behaviors associated with HIV transmission School settings are an important venue for reaching adolescents nationwide with effective prevention education and most states h ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health

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