Award Data

PROJECT SUMMARY / ABSTRACTThe objective of this Phase II proposal is to further develop a novel device for ocular anesthesia based on thermo-electric cooling. Intravitreal injection therapy (IVT) is one of the most commonly performed procedures in all of medicine, with approximately 7 million injections in the USA in 2016. Ocular anesthesia is required, both for patient safety and for tolerability ...

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

This SBIR addresses EPA’s need for improved sampling and analysis technologies to detect Per- and Polyfluoroalkyl Substances (PFAS). PFAS are used in firefighting sprays, at airports, and for wild fires, and have been used in textile treatments (e.g., it is a component in Scotchgard). It is estimated that 65 million Americans are at risk of PFAS exposure in their drinking water. Seacoast propose ...

Advances in materials and automation are rapidly reshaping the American manufacturing economy. These advances must be embraced to sustain a strong manufacturing sector in the United States. Additive manufacturing is possibly the fastest growing example of this trend, growing at an astonishing compound annual growth rate of 25.7%. The plastic materials market for additive manufacturing, valued at $ ...

Need: People are exposed to formaldehyde, a carcinogen found in building materials. Highly sensitive, real-time formaldehyde sensors would improve human safety by alerting users to harmful concentrations. _x000D_ _x000D_ Technical Feasibility: Vaporsens produces chemical sensors based on novel organic nanofiber technology. Phase 1 results demonstrated high selectivity, rapid-response time, and dem ...

Recognizing the need to monitor formaldehyde gas in residential and industrial buildings,_x000D_ Giner, Inc. (Giner) will continue the successful work started in Phase I and will develop,_x000D_ fabricate and demonstrate a formaldehyde gas monitor that is capable of continuously_x000D_ measuring formaldehyde in the range of 0-2000 parts per billion (ppb) with a resolution of 10 ppb. The wireless c ...

Of the 300 million tons of plastic produced per year most will require 500 years to biodegrade. Currently only 9% is recycled, and 50 million tons of thermoset plastic produced annually that can't be recycled. _x000D_ _x000D_ This project will develop a sustainable and easily biodegradable polycarbonate plastic that is uniquely a recyclable thermoset resin. We call it a thermosetting thermoplastic ...

Advances in clinical research have yielded many evidence-based guidelines to help clinicians provide the right care for the right patient at the right time; however, studies suggest that nearly half the time, that care does not reach the patient. Clinical decision support (CDS) is an information technology-enabled method to identify missed opportunities and optimize care. This proposal seeks to sy ...

Radiotherapy, a key anticancer therapy, acts not only by killing cancer cells, but also by activating the body's immune system to attack the remaining cancer cells. However, the immune-stimulating effect is weakened by the tumor's capacity to reprogram immune cells, particularly macrophages, so that they instead actively promote tumor growth. RP-185 (Riptide Biosciences, Vallejo, CA),an engineered ...