Award Data

PROJECT SUMMARY / ABSTRACTThe objective of this Phase II proposal is to further develop a novel device for ocular anesthesia based on thermo-electric cooling. Intravitreal injection therapy (IVT) is one of the most commonly performed procedures in all of medicine, with approximately 7 million injections in the USA in 2016. Ocular anesthesia is required, both for patient safety and for tolerability ...

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

Traditionally, implementation of dedicated, continuous nuclear and radiological monitoring systems for identifying and tracking nuclear materials out of regulatory control is associated with high operational burdens. Although video and images from cameras are helpful in assessing threats, the raw, unstructured data require time-intensive human interaction to extract the relevant actionable informa ...

The implementation of continuous nuclear and radiological monitoring systems enabling the automatic detection and tracking of potential nuclear threats is traditionally associated with a high operational burden. Sensors typically have to be monitored by dedicated personnel, who must investigate detection events in a timely manner; however, high nuisance alarm rates can rapidly overwhelm already-ta ...

Drug overdose is now the leading cause of death for Americans under 50 years old, with fentanyl claiming more lives than any other drug.Alarmingly, the problem is increasing, with fentanyl overdoses claiming nearly twice as many lives in 2016 compared to 2015.In addition to users, first responders are at risk for coming into contact with fentanyl as they perform their duties.Fentanyl is extremely ...

To address the DHS need to rapidly detect radio interference of critical radio frequency (RF) communications channels utilized by first responders, Physical Optics Corporation (POC) proposes to develop a new Miniature Intelligent Spectral Analyzer (MISCAN) device based on a combination of commercial off-the-shelf (COTS) electronic components in a custom software-defined configuration along with in ...

As Internet of Things (IoT) and mobile devices become increasingly popular and widely used, the security of the firmware running on these devices is paramount.However, due to the lack of an efficient and scalable analysis framework, combined with the increasing pressure to get products to market as quickly as possible, the software running on these devices is never properly checked for security vu ...

A Phase I SBIR is proposed for the development of a wearable sensor to protect law enforcement and first responders from inadvertent exposure to potentially toxic levels of fentanyl and/or fentanyl analogs.The Phase I project will demonstrate the ability of the new sensor to selectively detect the presence of fentanyl analog vapors from solid samples or air-borne particulates in concentrations bel ...

DHS has an unmet need for measuring ultra-high-intensity, near-field blast overpressure caused by internal blast within a commercial aircraft explosive threat environment in order to facilitate characterization of blast effects to commercial aircraft structures.The goal of this DHS SBIR OATS project is to deliver advanced thin, flexible, conformable, multi-sensing-point film sensor technology for ...