Award Data

PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

Project Summary The objective of Microsurgical InnovationsMSIin this proposal is to develop a biodegradable vascular coupling deviceVCDwhich would replace the hand suturing technique currently used to connect arteries and veins in microvascular and macrovascular end to end vascular repair surgeriesOur device works for both arteries and veins and can rapidly connect the two vessel ends together in ...

7. Project Summary/Abstract We propose to develop a Biological Small-angle X-ray Scattering (BioSAXS) station for the Compact Light Source, a powerful new generation of X-ray sources, which will enable biologists and biochemists to pursue state-of-the-artresearch in macromolecular structure studies in their own laboratories. The frontier of structural biology is the determination of large macromol ...

The inability to plan in real-time is a major reason why robot manufacturing is restricted to high-value, high-volume products, in carefully engineered factories where robots blindly repeat pre-programmed trajectories. Today, robots simply cannot generate collision-free motion on the fly. We are solving this core problem—real-time motion planning in unstructured, fluid environments and on divers ...

Project Summary Abstract Cytobank is the leading cloud based platform for analysis and storage of single cell flow and mass cytometry datatechnologies that are essential for investigating the interplay between the immune system and disease conditions including cancerThere are numerous data analysis steps between raw data and insight especially for many single cell technologieswhere the data analys ...

DESCRIPTION provided by applicant The growing populations of the elderly and those with type II diabetes are at high risk for developing chronic wounds that are slow to heal Effective therapeutics to promote wound healing could significantly improve the lives of these people Normal wound healing involves a coordinated cascade of events that are stimulated in part by the hypoxia that results f ...

DESCRIPTION (provided by applicant): Objective: This Phase 1 SBIR proposes to optimize the interface and interaction of a digital translation of Evidence Based Falls Prevention programs for use across the continuum of care and community living that affordseasy adoption, adherence and monitoring of falls prevention exercises for all stakeholders including those with limited technical experience. Pu ...

DESCRIPTION (provided by applicant): The goal of this research is to develop an economical, safe, effective therapy to reverse the activity of the catalytic component, LF, of the Bacillus anthracis toxin (lethal toxin), within the cytoplasm of the intoxicated cell. Success in achieving this goal will lead to better outcomes than currently seen with antibiotics or antitoxins like raxibacumab or PB ...

PROJECT SUMMARY Recovery from substance use disorders (SUDs) is greatly impacted by the cognitive and emotional state of the individual, and learning new thought and behavioral patterns can facilitate successful treatment and recovery. Specifically, fluctuations in stress or anxiety can trigger lapses to drug use. Even when actual use is avoided, stress-induced craving is likely to be distracting ...

DESCRIPTION provided by applicant Despite the introduction of newer triazoles and echinocandins invasive fungal infections IFIandapos s including invasive candidiasis IC remain very difficult to treat with currently available antifungals The annual cost burden of treating nosocomial fungal infections exceeds $ billion a year in the United States alone Worldwide the annual incidence o ...