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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 343- Cognitive Assessment and Monitoring Platform For Integrative Research (CAMPFIRE II)

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer survivors commonly report cognitive impairments following chemotherapy. With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment. This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits. To address ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 345: RadTox- Measuring Radiation Toxicity using Circulating DNA

    SBC: DiaCarta, Inc.            Topic: NCI

    The QuantiDNA RadTox System is a unique, patented technology that measures tissue damage shortly following injury using cell-free DNA from a drop of blood. Premised on murine and primate studies showing circulating DNA is logarithmically increased with whole-body radiation dose, RadTox has the potential to overcome many of the species-specific challenges faced by biomarker panels. The phase I SBIR ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 349: Quantum Dot FRET Immunoassay to Quantify Intramolecular Epitopes of Analytes in Tissue Sections

    SBC: Ocean Nano Tech LLC            Topic: NCI

    This proposal is to develop a novel slide based proximity assay platform to quantify protein phosphorylation on tissues. The novelty of this assay platform is derived from the use of the quantum dot with two emission peaks for fluorescence resonance energy transfer (FRET): one emission as internal standard and the other as FRET donor. Change of ratio of the two emission intensity during the FRET c ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A MULTIPLEXED REMOTE SYSTEM FOR FILOVIRUS DISEASE SURVEILLANCE

    SBC: Cellmic, LLC            Topic: NIAID

    Proposes an advanced Ebola and Marburg disease telemonitoring and assessment platform that will enable the digital modernization of point of care diagnosticsdisease surveillanceand healthcare screening by minimally trained personnel at the point of careOffering a complete diagnostics solutionthe platform includes a microfluidics assay for the detection of infections caused by Ebola and Marburg fil ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. The purpose of this contract is to develop an assay to detect minor populations of resistant variants in blood specimens from HIV-infected individuals with HIV RNA viral loads above 1000 copies/ml

    SBC: ALDATU BIOSCIENCES, INC.            Topic: NIAID

    Antiretroviral therapyARTreduces mortality and morbidity in HIV infected individualsbut specific HIV mutationsDRMsare associated with resistanceIt is now known that certain DRMs can contribute to virological failure even at very low concentrationsbut standard tests are inadequately sensitive to detect these minor variantsMethods to detect minor variants that contribute to HIV virological failure a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. SBIR TOPIC 096:Novel Biodegradable Stents for Neonatal Aortic Coarctation

    SBC: 480 Biomedical Inc.            Topic: NHLBI

    Aortic coarctation is a common congenital heart condition that is usually recognized during the neonatal period early after birth The usual treatment is open surgery Non surgical catheter based stent therapy is not available to treat neonatal aortic coarctation because children outgrow commercially available metallic stents Absorbable stents might revolutionize the treatment of aortic coarctation ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Delivery of passive immunity against HIV using commensal vaginal Lactobacillus bioengineered to secrete broadly neutralizing domain antibodies

    SBC: OSEL, INC.            Topic: NIAID

    DESCRIPTION Women bear the brunt of the global AIDS epidemic due in part to their inherent social and biological vulnerability Biologically the cervical and vaginal mucosae are vulnerable targets for HIV transmission In healthy women of childbearing age mucosal antibodies and microbiota including Lactobacillus jensenii help protect these surfaces and serve to block the colonization and infe ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. SAMBA HIV-1 Semi-quantitative Test for resource limited settings

    SBC: DIAGNOSTICS FOR THE REAL WORLD LIMITED            Topic: R

    DESCRIPTION provided by applicant SAMBA HIV Semi quantitative Test for resource limited settings Project Abstract The ultimate aim of this project is to develop a CE marked and or FDA approved diagnostic platform for viral load monitoring of HIV infected patients in point of care POC and resource limited settings Currently available viral load tests are not suitable for such settings du ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. A Combination Therapy Approach to Treating Drug Resistant Fungal Infections

    SBC: Amplyx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Despite the introduction of newer triazoles and echinocandins invasive fungal infections IFIandapos s including invasive candidiasis IC remain very difficult to treat with currently available antifungals The annual cost burden of treating nosocomial fungal infections exceeds $ billion a year in the United States alone Worldwide the annual incidence o ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Dendritic Cell-Targeted HIV Vaccine Product

    SBC: AVANT IMMUNOTHERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION This proposal is a unique collaboration between a small but full capability biotechnology company and a premier academic institution and laboratory to develop a novel product for clinical trials to prevent HIV infection This proposal describes a vaccine product aimed to provide a feasible and nontoxic way to elicit strong immunity in humans to HIV proteins and it will provide an ad ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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