Award Data

The long term goal of this proposal is to develop a safeeffective and user friendly vitrification system for cryopreservation of whole human ovariesIn the U Sovergirls and women ageare diagnosed with cancer annuallyWhile improved diagnosis and treatment have led to increased survival ratesin premenopausal andin childhood cancer patientsdevastating side effects of cancer therapies include premature ...

PROJECT SUMMARY Improved Amputee Quality of Life Enabled by TailoredSelf Regenerating Energy Storage Device forPowered Prosthetics Poweredmotorized prosthetics enable users to more naturally perform taskssuch as climbing stairs or rising from a seated positionHowever because the power requirements fluctuate during the gait cyclethe current battery system is not energy efficient and also since ener ...

Limited information is available about early human placentation when many pregnancy pathologies originateTo address this knowledge gap and begin development of robust diagnostic tool to manage pregnancy complicationswe propose a pilot study based on a highly sensitive immune assay and our company s base technologyTrophoblast Retrieval and Isolation from the CervixTRICTRIC uses a Pap smearconsidere ...

Roughlypeople in the United States will suffer a spinal cord injurySCIthis yearFor the vast majority of themthe injury will leave them incapable of walking orif they have suffered a cervical SCIentirely dependent upon others for assistance in all of their activities of daily living from feeding to personal careMore importantlychances of improvement as a result of therapeutic interventions are blea ...

ABSTRACT SkillTalkCommunication Training around Sexual Health Topics for Parents of Youth with Autism Spectrum Disorder Adolescents with Autism Spectrum DisorderASDface a range of impairments in social interaction and communication settingsincluding those involved with sexual communication and behaviorLike their neurotypical peersadolescents with ASD need comprehensive sexual education to learn an ...

AbstractIn themillion laparoscopic surgeries performed annually worldwideachieving peritoneal access for insufflation accounts for one third of the associated complicationsPeritoneal access is typically achieved using the Veress needleHoweverthe use of the Veress needle has been identified as the source ofof the complications associated with laparoscopic proceduresIt has been shown that complicati ...

Ninja Theranostics for overcoming the drug delivery barriers to pediatric brain tumor Project Summary Abstract Pediatric brain tumorsPBTsare the leading cause of cancer related morbidity and mortality among childrenVincristineVCRhas been approved to treat PBTsbut its inability to cross blood brain barrierBBBblood brain tumor barriersBBTBand dose limiting neuropathy have greatly limited its clinica ...

AbstractBrain swelling is a serious complication of traumatic brain injuryTBIischemic stroke and other serious conditionsTBI and stroke afflictM andK persons per year in the US aloneThey are a costly health care burden and a devastating social burdenCurrent treatments for brain swelling are limited and generally ineffectivehighlighting the dramatic unmet need for better therapeuticsA better unders ...

PROJECT SUMMARY Traumatic brain injuriesTBIincluding concussionsare an area of significant unmet need with no approved therapeutics and a national burden of$billion annuallyTBI is the global leading cause of post injury death and disabilityand overmillion Americans sustain a TBI each yearThe tremendous incidence and long term consequences of TBI highlight the considerable epidemic at handand the n ...

AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...