Award Data

PROJECT SUMMARY / ABSTRACTThe objective of this Phase II proposal is to further develop a novel device for ocular anesthesia based on thermo-electric cooling. Intravitreal injection therapy (IVT) is one of the most commonly performed procedures in all of medicine, with approximately 7 million injections in the USA in 2016. Ocular anesthesia is required, both for patient safety and for tolerability ...

Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

The QIF standard shows the promise of offering an environment where best-in-class metrology applications can be linked to yield solutions that are automated, optimized, adaptive, and traceable, maintaining the agility required to ensure U. S. global competitiveness. While the QIF standard has reached a substantial level of comprehensiveness and maturity, the embodiment of the standard in actual, c ...

Network measurement is a critical element in networks but it has largely been an afterthought and inadequately secured. With the emergence of Information-Centric Networking technologies, specifically the popular open source Named-Data Networking (NDN), there is the early stage opportunity to create a useful and flexible network measurement system that can accommodate a range of network probes. Thi ...

This Phase II SBIR project will continue the development of an optical sorter that will be used to estimate drop sizes in sprays. The optical sorter will determine the size of drops in the 0.1 to 10 microns range. Drops in this size range are prevalent in the automobile industry, where the fuel injection pressures have increased tremendously over the past two decades. These newer injectors provide ...

Our innovation is a low cost, sensitive, quantitative biosensor that can detect many biomarkers on the same chip. Our sensor consists of vertically aligned silicon nanowires. The silicon nanowires’ high surface area to volume ratio makes them sensitive to the environment around them and can thus lead to high sensitivity detection. Each of the nanowires can be functionalized to be sensitive to ei ...

In this SBIR effort, Nikira Labs Inc. proposes to develop a compact Raman fiber optic probe with inline spectral filtering that improves fiber-coupled Raman measurements by filtering out Raman scattering from the excitation fiber and elastically scattered laser light from the collection fibers. The technology will enable compact fiber probes for Raman studies and complement existing NIST Raman spe ...

In this SBIR effort, Nikira Labs Inc. proposes to develop and deliver a high-resolution (< 1.2 micron) microscope that can rapidly (< 60 seconds) image a large field of view (> 1 cm2). The instrument will provide a wide array of imaging modalities, including brightfield, darkfield, fluorescence, quantitative phase, and Rheinberg imaging. In Phase II, Nikira Labs will fabricate, test, and deliver a ...