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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 343- Cognitive Assessment and Monitoring Platform For Integrative Research (CAMPFIRE II)

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer survivors commonly report cognitive impairments following chemotherapy. With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment. This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits. To address ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 345: RadTox- Measuring Radiation Toxicity using Circulating DNA

    SBC: DiaCarta, Inc.            Topic: NCI

    The QuantiDNA RadTox System is a unique, patented technology that measures tissue damage shortly following injury using cell-free DNA from a drop of blood. Premised on murine and primate studies showing circulating DNA is logarithmically increased with whole-body radiation dose, RadTox has the potential to overcome many of the species-specific challenges faced by biomarker panels. The phase I SBIR ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 349: Quantum Dot FRET Immunoassay to Quantify Intramolecular Epitopes of Analytes in Tissue Sections

    SBC: Ocean Nano Tech LLC            Topic: NCI

    This proposal is to develop a novel slide based proximity assay platform to quantify protein phosphorylation on tissues. The novelty of this assay platform is derived from the use of the quantum dot with two emission peaks for fluorescence resonance energy transfer (FRET): one emission as internal standard and the other as FRET donor. Change of ratio of the two emission intensity during the FRET c ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Small Molecule Treatments to Enhance Neurological Recovery After Stroke

    SBC: Stemetix, Inc.            Topic: NINDS

    PROJECT SUMMARYStroke is a major public health problem in the U Sand worldwideIt is defined as an area of brain damagegenerally due to the sudden occlusion of an artery in or leading to the brainStroke can cause weaknessnumbnessvisual disturbancespeech difficultybalance problemsand memory lossamong other symptomsWhile good treatments exist to limit stroke in the first few hours after occurrencefew ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. MicroRNA-based Radiation Biodosimeter (MiRAD) Phase II

    SBC: Chromologic LLC            Topic: NIAID

    Abstract In response to PAthe broad long term goal of this project is to develop a portable radiation biodosimeter to be used at the point of carePOCfor assessing precise radiation exposure and susceptibility for acute radiation syndromeARSwithin the firstdays of exposure starting withL of blood collected from a finger stick and a turnaround timeTATof less thanminutesThe device measures changes in ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. IND-enabling studies on novel Cav3 T-channel modulators for treatment of neuropathic pain

    SBC: AFASCI, INC.            Topic: NINDS

    PROJECT SUMMARY Neuropathic pain remains a poorly managed medical condition affecting more thanbillion people worldwideOvermillion people suffered from diabetic neuropathy and neuropathic pain in the US alone inThe current standard of care is insufficientTopical applications and systemic treatment with existing analgesicsincluding opioidsleave millions sufferingMore thanof these patients are refra ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Relative Bioavailability of Subcutaneous Insulin over Extended Durations of Infusion Set Use

    SBC: Capillary Biomedical, Inc.            Topic: 200

    PROJECT SUMMARYABSTRACT Capillary Biomedical Incis developing an infusion setcatheter cannula inserterfor the treatment of diabetes mellitus with continuous subcutaneous insulin infusionCSIIThe Capillary infusion cannula has been reinvented to include kink resistancean internal reinforcing coilmultiple outlet portsan `effortlessandaposautomatic inserter and other performanceimproving design elemen ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Developing a highly sensitive, rapid, handheld vaginal swab test for the detection of Chlamydia trachomatis

    SBC: PHASE DIAGNOSTICS LLC            Topic: NIAID

    Project Summary Phase Diagnostics is aiming to create the new gold standard diagnostic for the detection of sexually transmitted infectionsSTIsThe company aims to replace lab based assays for Chlamydia trachomatisCTand expand testing accessibility to previously unreachable settingsThe technology combines the ease of use and very low cost of rapid point of carePOCdiagnostics with the very high accu ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Tortuous vascular accessibility with a novel coaxial active deflectable microcatheter

    SBC: Agile Devices, Inc.            Topic: NHLBI

    Project Summary The goal of this project is to introduce a new microcatheter that will significantly improve an interventional radiologist s ability to navigate across small blood vesselsMicrocatheters are designed to reach small vascular targets from access points such as the femoral or radial arterieslocated up tocm awayInterventional radiologists use these devices to treat a wide variety of ail ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Development of modified human thioredoxin as an inhaled biologic therapeutic for cystic fibrosis

    SBC: Orpro Therapeutics, Inc.            Topic: NHLBI

    SUMMARY Effective management of obstructive pulmonary diseases characterized by thickenedhighly viscoelastic mucus represents a significant unmet medical needespecially in cystic fibrosisCFan inherited disease affecting approximatelyindividuals in the USIn CFgenetic dysfunction of the CFTRCystic Fibrosis Transmembrane Regulatortrans membrane channel results in impaired mucociliary transport and de ...

    SBIR Phase II 2018 Department of Health and Human Services

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