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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.


    SBC: DIAGNOLOGIX, LLC            Topic: NCI

    Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development and Evaluation of a Simulated Prototype to Dynamically Adjust Ambient Environments to Promote Affective Regulation in Individuals with Autism Spectrum Disorder

    SBC: SpaceFactory, Inc.            Topic: na

    The goal of the Phase I proof-of-concept project is to determine if affective and physiological regulation in individuals with autism spectrum disorders (ASD) can be promoted through dynamic adjustments in the environment. This goal will be addressed through the execution of two objectives: (1) development of an Internet of Things (IoT) prototype digital interface; and (2) evaluation of environmen ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Assistive Technology Enabling Communication

    SBC: Pison Technology, Inc.            Topic: na

    This project furthers development of an effective early-stage assistive communication device for patients with Amyotrophic Lateral Sclerosis (ALS). The wearable assistive communication device uses electromyography (EMG) signals to empower users with ALS and other neuromuscular disabilities to control household devices (e.g. computers) and communicate within their environment. Increasing the capabi ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Development of Rapid Antigen Detection Assays For Taeniasis

    SBC: Kephera Diagnostics, LLC            Topic: ODCDC

    This proposal addresses the significant public health threat posed by the spread of Taenia soliumthe pork tapewormin at risk human populationsInfection with Tsoliumor Taeniasiscan lead to Cysticercosiscaused by the migration and encystment of larval Tsolium in the central nervous systemCysticercosis is a severe to fatal disease which affects overmillion people worldwideprincipally in less develope ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Developing Species Specific Human Taeniasis Coproantigen Detection Immunoassays

    SBC: QOOLABS, INC.            Topic: ODCDC

    As the major cause of acquired epilepsy in developing countriesNeurocysticercosisNCCis the infection of the human nervous system by the larvae of the pork tapewormTaenia soliumReportable cases are seen in non endemic countries because of increasing travel and immigrationMany infected persons are unaware of their infection or the potential risks of transmission to othersIt is important to control a ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Development of a Benchtop Laboratory Platform for Amplicon Deep Sequencing

    SBC: Trace-Ability, Inc.            Topic: ODCDC

    This proposal focuses on a solution that would address the above issues by enabling a compact and completely automated closed platform that allows DNA libraries preparation from clinical samples for deep sequencing on the MiSeq Illumina systemThe resulting benefits would be process efficiency and accessibility to NGS in parts of the world where proper laboratorieshighly skilled personnelor simply ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Development of Novel Broad Spectrum Antimicrobial Corneal Tissue Storage Solutions

    SBC: IFYBER, LLC            Topic: ODCDC

    Endophthalmitis is a severe condition caused by inflammation of the ocular cavity and is a significant complication of corneal transplant proceduresoften being caused by microbial contamination of the donor tissueThe introduction of antibiotics into corneal tissue storage solutions in thes drastically lowered the incidence of bacterial endophthalmitis has drastically decreasedhoweverfungal endopht ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Synergistic Antifungal Cocktails for Corneal Storage

    SBC: Giner, Inc.            Topic: ODCDC

    Fungal endophthalmitis is an infection inside the eye after corneal transplant surgery caused by contamination of the transplanted tissueAccording to the Eye Bank of Americathe incidence of postsurgery endophthalmitis more than doubled fromtoand thatof the culture positive cases were due to Candida yeastEnvironmental contamination as well as current corneal preservation conditions contribute to th ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Dried bead format one step RT PCR assay for rabies screening

    SBC: Crosslife Technologies Inc.            Topic: ODCDC

    We propose in this proposal to complete the developmentvalidation and pursuing appropriate regulatory approvals or waivers for a RABV One Step RT PCR test kit commercializationThis rabies testing kit is planned to be developed as a user friendlyrapidand specific assay with the targeting sample types including salivaeyewashesand skin biopsiesThe kits are intended to be used for rabies transmission ...

    SBIR Phase I 2018 Department of Health and Human Services

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