Award Data

PROJECT SUMMARY / ABSTRACTThe objective of this Phase II proposal is to further develop a novel device for ocular anesthesia based on thermo-electric cooling. Intravitreal injection therapy (IVT) is one of the most commonly performed procedures in all of medicine, with approximately 7 million injections in the USA in 2016. Ocular anesthesia is required, both for patient safety and for tolerability ...

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

The broader impact/commercial potential of this project is the rapid, cost-effective detection of natural gas leakage to improve public safety, mitigate global climate change, and decrease product loss. Natural gas is the largest provider of power in the United States. However, more than 80 Tg of leakage occurs at well pads and pipelines during production alone. Such leakage poses a public health ...

This STTR Phase I project will remove the most critical roadblock to making long-lasting batteries from safe and economical zinc and air. Zinc is plentiful in the U.S. and zinc-air batteries have the potential to hold more than five times the energy of current lithium-ion batteries, but a key challenge for making rechargeable zinc-air batteries is that the zinc inside the battery naturally forms s ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project will be the development of sensor-embedded "smart" drinkware (i.e., stirrers, straws and cups) to actively alert consumers prior to consumption of a "spiked" beverage, and thus provide a proactive way to prevent drug-facilitated sexual assault. This sensor technology is based on "smart" molecularly im ...

The broader impact/commercial potential of this project will enable Unmanned Aerial Systems (UAS or drones) to safely and reliably operate from moving vehicles and moving vessels at sea. There is an immediate need for this capability in many industries. In commercial fishing, drones will replace manned aircraft for fish-finding operations, radically reducing cost and risk. In maritime security, dr ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase II project will be to develop a new tool to safely and nondestructively deliver genes and other materials into large numbers cells at the same time. New forms of therapies for cancer and other intractable diseases take advantage of a patient's own cells, re-engineered in the laboratory to target a tumor ...

This SBIR Phase I project aims to further the development a novel nanoparticle-based synthetic platelet technology for the treatment of internal, non-compressible hemorrhage after traumatic injury. Trauma is the leading killer of people aged 1-46, and uncontrollable hemorrhage after injury is the cause of 35% of pre-hospital trauma deaths and 90% of military combat casualties. This is because ther ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to reduce the power consumption of display and lighting products by 90%. It will do so by enabling the pervasive use of light emitting diodes (LEDs) in such products. LEDs consume substantially less power than other display/lighting technologies and also offer benefits such as superior pic ...