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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Long-acting PTH for hypoparathyroidism

    SBC: Extend Biosciences Inc.            Topic: NIDDK

    Project Summary Hypoparathyroidism is a rare disease that results from a deficiency or inability to make sufficient amounts of parathyroid hormonePTHUntreated or inadequately treated hypoparathyroidism leads to clinically significant mineral related metabolic issues including hypocalcemiawhich leads to heart arrhythmiasspasms of the vocal cordsand seizuresCurrent management of the disease for the ...

    SBIR Phase II 2017 Department of Health and Human Services
  2. Eliminating Ventricular Tachycardia:First in Human Clinical Trial using the Durablate Catheter

    SBC: Thermedical Inc.            Topic: NHLBI

    Ischemic ventricular tachycardiaVTcauses more than half of thesudden cardiac deathsSCDthat occur annually in the United StatesImplantable cardioverter defibrillatorsICDsare the standard of carebut they are expensivethe total cost of an ICD implant exceeds $and not curativePatients who receive ICDs are subject to periodic shocks to halt episodes of VTand those shocks can be traumaticRF ablation rep ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntington's Disease

    SBC: BioSensics LLC            Topic: 106

    ABSTRACT The principal means of measuring motor impairment in Huntington diseaseHDis the Unified Huntington s Disease Rating ScaleUHDRStotal motor scorewhich is subjective and categoricalWearable sensors could enable objectivesensitivecontinuous assessment of motor impairments in individuals with a variety of neurological movement disordersThis is important because large amounts of objective data ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Long-acting ghrelin for the treatment of cancer cachexia

    SBC: Extend Biosciences Inc.            Topic: 102

    Cachexia is a complex syndrome characterized by involuntary weight loss and skeletal muscle wasting that leads to fatigueweakness and a loss of appetite that is not reversed by increased caloric consumptionMore than half of all cancer patients develop cachexia and it is responsible for more thanof all cancer deathsNumerous complications associated with cachexia include an impaired response to drug ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Adapting the Berkeley Big Data Analytics Stack to Genomics and Health

    SBC: Curii Corporation            Topic: 400

    Project Summary We propose building a computational platform based on the high performance Berkeley Big Data Analytics StackBDASto support a new ecosystem of Clinical Decision SupportCDSapplicationsThis platform will make it fastereasierand less expensive to develop molecular Clinical Decision Support SystemsThese systems require real time queries of globally distributed dataefficient machine lear ...

    SBIR Phase II 2017 Department of Health and Human Services
  6. Development of PAR2 Pepducins as a Novel NASH Treatment

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: 300

    Non alcoholic steatohepatitisNASHis characterized by fatty changes in the liver with inflammation and hepatocellular injury that in advanced stages leads to fibrosiscirrhosis and high mortality ratesNASH is frequently associated with other common metabolic abnormalitiessuch as insulin resistance and visceral obesityLiver transplantation is currently the only effective therapeutic approach for seve ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. Phase II: Research and Commercialization of TruT Algorithm for Free Testosterone

    SBC: FUNCTION PROMOTING THERAPIES, LLC            Topic: NIA

    The measurement of testosteroneTlevels is central to the diagnosis of androgen disorderssuch as hypogonadism in men and polycystic ovary syndromePCOSin womenCirculating T is bound with high affinity to sex hormone binding globulinSHBGand with substantially lower affinity to albuminonly the free fraction is biologically activeConditions that affect SHBG concentrationssuch as aging and obesityalter ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. A sample-to-answer diagnostic for neonatal bloodstream infections

    SBC: HELIXBIND INC.            Topic: NICHD

    PROJECT SUMMARY Neonatal septicemia is a life threatening disease that affects roughlyout of everylive births in the USwheredo not surviveCaused by an infection of the newborn bloodstream either at the time of birth or soon afterthe disease s initial clinical manifestations are often non specificvariableat times subtleand often common to signs of stressThus a core requirement to both to rule in a ...

    SBIR Phase II 2017 Department of Health and Human Services
  9. Service-based Command and Control (C2) for the Forward Deployed Energy and Communications Outpost (C2-FDECO)

    SBC: Charles River Analytics, Inc.            Topic: N091082

    Advances in the capabilities of the US Navys fleet of unmanned underwater vehicles (UUVs) have led to an array of assets capable of executing a number of operational missions. The Navy is investing in extending the reach of these assets to provide mission capabilities from longer range and over longer duration. The FDECO Innovative Naval Prototype (INP) program addresses one challenge of current U ...

    SBIR Phase II 2017 Department of DefenseNavy
  10. Selective Depletion of Insulin-Specific B cells to Prevent Type 1 Diabetes

    SBC: Akston Biosciences Corporation            Topic: 200

    PUBLIC DESCRIPTION Akston is developing a subcutaneously administered therapeutic for preventing or delaying the onset of diabetes in pre diabetic patients who are at high riskthose who display autoantibodies for insulinGADIAand ZnTfor developing TypediabetesT DThe therapeutic is designed to delete a subset of B cells that likely play a role in disease development using a patient s own antibody di ...

    SBIR Phase II 2017 Department of Health and Human Services

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