Award Data

DESCRIPTION (provided by applicant): Flavonoids are ubiquitous secondary metabolites in plants with many known health benefits, which are mostly ascribed to their potent anti-oxidant activity. However, a search for novel nicotinic ligands, using high throughput pharmacological screening of a native plant extract library, and subsequently a pure flavonoid library, led to the highly surprising con ...

DESCRIPTION (provided by applicant): An estimated 5.4 million Americans had Alzheimer's disease in 2012 and a 50% increase in this number is expected by 2030. The majority of these patients (70%) will live at home where they receive 75% of their care frominformal caregivers, unpaid individuals such as family members, friends, and neighbors. These caregivers provide valuable services, often a ...

DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) and our partners propose a minimally-invasive system for continuous monitoring of potassium. Measurement of blood levels of potassium is important in clinical medicine. Abnormalities of potassium, common in heart and kidney disease, can be aggravated by many medications used to treat these disorders leading to arrhythmias and ...

DESCRIPTION (provided by applicant): Fungal infections, particularly in immunocompromised patients, are a serious and growing problem. Although antifungal therapeutics have improved greatly, failures and relapse are common. Aspergillus fumigatus is a primary cause of these infections in several patient populations: transplants, leukemics, genetic deficiencies such as chronic granulomatous disease ...

DESCRIPTION (provided by applicant): In orthopedic surgery, surgeons have to handle not only bone but also the surrounding soft tissue, including muscle, fascia, tendon, ligament and capsule. Successful handling of these tissues is often the key to high reproducibility, good soft tissue healing, and restoration of overall function. However, there are no widely used, robust methods for intra-opera ...

DESCRIPTION (provided by applicant): The dental profession has searched for many years for additional real time chair-side measures to provide objective measures to aid in the monitoring of periodontal health and early diagnosis of disease. Research efforts have produced solid evidence that constituents present in saliva can provide important complimentary diagnostic information, and have the po ...

DESCRIPTION (provided by applicant): Eden Medical, Inc. is pleased to submit this Phase 1 SBIR proposal to develop the Infrared Eyes (iREyes) imager system, an affordable and powerful mobile health (mhealth) tool for healthcare. The hand-held iREyes system will acquire both thermal and visible spectrum imagery to quantify healing via foot thermal indexing methodology. The iREyes will offer a use ...

DESCRIPTION (provided by applicant): Prior to the advent of capsule endoscopes (CE), imaging and examination of the small bowel was difficult. Today, a patient swallows the capsule with an imaging camera, which is then carried passively through the gastrointestinal (GI) tract by peristalsis. The onboard camera captures images of the lumen wall several times per second over a 7-11 hour period, rela ...

? DESCRIPTION (provided by applicant): Polycystic kidney diseases (PKD) are a group of inherited disorders characterized by progressive cyst development in the kidney resulting in bilateral renal enlargement and often end stage renal disease (ESRD). The most common form of PKD, autosomal dominant PKD occurs at a frequency of 1:400 to 1:1000. Currently, there is no treatment that can slow or re ...

DESCRIPTION (provided by applicant): While it has been demonstrated that gene mutations are associated with an increasing number of neurodegenerative syndromes, environmental neurotoxicants remain a key factor in the etiology of many such diseases. For example, exposure to pesticides such as maneb and paraquat increase the risk of developing Parkinson's disease. Unfortunately, there is no opt ...