Award Data

DESCRIPTION (Adapted from the application): Penicillin-resistant bacteria pose a serious threat to human welfare. This project will generate new products designed to defeat resistant microorganisms. The most prevalent cause of bacterial resistance involves the destruction of the antibiotic with the enzyme B-lactamase. There are more than 255 known B-lactamases, whi ...

DESCRIPTION (provided by applicant) Every year millions of hearing tests are conducted in the U.S. for a variety of reasons, including diagnosis of ear disease, evaluation of communicative function, monitoring effects of noise and ototoxic medications. prospective research studies, and fitting of hearing aids. Although there is a "standard" hearing test method, th ...

DESCRIPTION: The number of persons in the United States with dementing disorders, now between 4-5 million, will quadruple in 50 years. One consequence of the progressive nature of dementia is that family caregivers must assume the role of primary decision makers. This Phase I proposal will develop an Internet-based prototype and companion CD-ROM Dementia Decision-making Guide based ...

We propose a fundamental study of filamentation in air that will combine the theoretical expertise at the University of Arizona in simulating these nonlinear phenomena, the experimental facilities at the University of New Mexico in ultrafast diagnostics,and the experience at Lite Cycles, Inc. in the design and construction of high-power, short-pulse lasers. In Phase I of this program, we will mak ...

DESCRIPTION (provided by applicant): This project will design, develop and evaluate an interactive multimedia program to provide integrated instruction about the embryology and anatomy of the adult human central nervous system. The program will also provide extensive self-testing for the competencies to be acquired through interaction with the software program. The ...

DESCRIPTION (adapted from applicant's abstract): The activity level of people tends to decrease after a spinal cord injury. Studies have reported that daily wheelchair propulsion activity level of an individual with a spinal cord injury (SCI) is not sufficient to maintain or improve their cardiovascular fitness level. Sedentary individuals with paraplegia and tetraplegia ...

DESCRIPTION (provided by applicant): Based on the extensive data generated during the phase I portion of our studies, there is sufficient and compelling information to support the further development of the highly lipophilic and blood-stable topoisomerase inhibitor, DB-67. In part, the pre-clinical and clinical evaluation of DB-67 is currently being supported by ...

DESCRIPTION (provided by applicant): Based on the extensive data generated during the phase I portion of our studies, there is sufficient and compelling information to support the further development of the highly lipophilic and blood-stable topoisomerase inhibitor, DB-67. In part, the pre-clinical and clinical evaluation of DB-67 is currently being supported by ...

DESCRIPTION (PROVIDED BY APPLICANT): DB-67 is a promising new silatecan (silylcamptothecin) analog that displays superior blood stability relative to the FDA-approved camptothecin congeners, topotecan and CPT- 11. DB-67 also exhibits a high degree of anti-cancer potency both in vitro and in vivo. DB-67 is a highly lipophilic camptothecin and active lactone levels pe ...

This proposal entails the fabrication of selective permeable reverse microemulsion derived elastomeric membranes which are fabricated using rapid prototyping (RP) techniques. Rp offers a significant advantage in that it is capable of forming membraneshaving controlled porosity and microstructural architectures on a three dimensional level rather than the two dimensional level attained by conventio ...