Award Data

Alameda Applied Sciences Corporation proposes to use its Filtered Cathodic Arc Plasma Deposition (FCAPD) process to apply reflective high-energy laser coatings to complaint polyamide substrates for space-based mirrors. FCAPD coatings have better adhesionand are denser and more stable than coatings deposited using other methods, such as, sputtering or evaporation. In addition, the internal stress o ...

Alameda Applied Sciences Corporation will use its proprietary Coaxial Energetic Deposition process to deposit a linearly-graded ceramic coating on the inside of gun barrels. This coating will transition smoothly from a fully ceramic interior surface, whichis exposed to the harsh firing environment, to a fully metallic base, which is directly interfaced with the metal barrel. Analytical tests will ...

The purpose of this Phase I effort is to investigate the effectiveness of using coatings to extend the life of gun barrels. The coatings will be deposited using Alameda Applied Sciences' proprietary Coaxial Energetic Deposition (CED) process, which iscapable of depositing virtually any metal or alloy and many types of ceramics to the insides of tubes, while using no moving parts. One of the major ...

The objective of this Phase-II proposal is to develop Alameda Applied Sciences Corporation's (AASC) Coaxial Energetic Deposition (CED) process to increase the life of gun barrels by depositing a protective refractory metal coating to the inside of thebarrel that can outperform and replace the electroplated chrome coatings that are presently used. This effort extends and builds upon AASC's promisin ...

Alameda Applied Sciences Corporation proposes to develop a new type of electric propulsion device dubbed the Magnetically Enhanced Vacuum Arc Thruster (MVAT). This thruster is itself a variant on the Vacuum Arc Thruster that has been demonstrated via a recently concluded Phase I SBIR contracts from NASA. The VAT was verified to be a throttleable low mass (150g) high efficiency (10% measured), high ...

DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...