Award Data

DESCRIPTION (provided by applicant): The primary goal of the Phase I effort is to establish the feasibility of fabricating waveguides to realize a significant, (10 fold), increase in performance in the output power of a picosecond pulsed green laser without increasing the peak pump power. The ultimate goal is to develop a fiber pigtailed, compact, cost-effective 530 nm picosecond laser producing 1 ...

DESCRIPTION (provided by applicant): This Phase I project will test the idea that mechanostress-sensitive, fluorescent polymers can detect structural changes induced in proteins following reaction of the protein with small molecule inhibitors. This concept will be tested and proven using recombinant acetylcholinesterase (AChE) an enzyme that is known to undergo catastrophic denaturation when it re ...

The objective of this proposal is to design and develop compact, efficient, electrically small, broadband antennas that are capable of handling high voltages of greater than 100 kV, and fit into small geometrical spaces of less than 40 mm in diameter and 50 mm in length. Previously insurmountable challenges to achieving the stringent requirements of simultaneous compact size, wider bandwidths, an ...

The objective of this proposal is to develop innovative concept designs for flat-panel, low-profile, smallest possible aperture, phased-array GBS receive antennas in the 10.5 – 13.5 GHz Ku-band and 20.2 – 21.2 GHz K/Ka-band. Furthermore, the objectives include that the antenna be realized within a 40” cross section. Conventional array antenna designs to meet the G/T requirement ...

This project will develop and demonstrate a prototype Modular Perfusion Bioreactor (MPB) for tissue engineering applications. While many unique styles of bioreactors have been proposed for various types of stem cell and tissue cultures, there is not a single, easy-to-use device that accommodates the multiple diverse needs of multiple tissue culture types.. In order to take advantage of recent ad ...

Pine Ridge Products LLC will introduce a tactical micro wind turbine that is highly efficient, robust, easy to use, maintain and transport. The Army is requesting a renewable energy system to reduce the amount of fuel used for small power loads. A vehicle mounted, efficient wind turbine system would improve self sufficiency on site by decreasing the need for fossil fuels. This will increase reliab ...

The objectives are to further the pre-clinical development of unique two-photon activated Photodynamic Therapy (PTD) triads that incorporate a photosensitizer, a tumor receptor targeting group, and an imaging functionality, providing a noninvasive treatment of recurrent and refractory Head and Neck (HandN) tumors deep below the skin surface, in an outpatient setting.

DESCRIPTION (provided by applicant): A Phase I SBIR program of preclinical development is proposed focusing on the development of an active specific immunotherapeutic called Cellarium for treatment of glial cell-based cancers. Successful completion of this project will establish the minimum level of therapeutic feasibility and lead to further development of the vaccine in preparation for f ...

DESCRIPTION (provided by applicant): This STTR application is to develop and test for eventual clinical use a new strategy for tumor specific anticancer drug delivery. The technology, Clostridia-directed enzyme prodrug therapy, or CDEPT, exploits the fact that certain non-pathogenic bacteria of the Clostridia genus, which only grow in the absence of oxygen (hypoxia), colonize the hypoxic and necr ...