Award Data

This Small Business Innovation research Phase I proposes the development of a practical and reliable in-vitro test for detecting the evidence of Mycobacterium tuberculosis (MTB) infection as an alternative to the tuberculin skin test (PPD-TST) and to the interferon gamma release assays (IGRAs). The proposed methodology will be a powerful detection technology in clinical diagnosis owing to its dete ...

Limb loss affects approximately 1.9 million people in the United States, 400,000 of whom have amputations above the knee. It is well established that lower-limb amputees show greater metabolic demands during gait and more limited mobility compared to non-disabled individuals. At present, there is no lower-extremity prosthesis available that can monitor the metabolic costs of the amputee. The propo ...

This project will bring interferometric synthetic aperture microscopy (ISAM), a powerful new method of computed microscopy, to bear on the problem of quantitative tissue assessment. The promise of tissue engineering, including wound healing, is limited unless the tissue is treated correctly at optimal times during growth. Therefore, continuous, nondestructive, microscopic 3-D visualization and qu ...

There is a substantial clinical need in both civilian and battlefield injuries for the repair and regeneration of large-volume-loss skeletal muscle tissue injuries. Current standards of care rely on rotational tissue grafts and often result in substantial morbidity, pain, and disfigurement. Luna Innovations Incorporated proposes the development of a hierarchically organized, superporous hydrogel c ...

IST Research proposes the creation of the Disease Early Warning Sensor System. The IST Research Team will bring together considerable experience to bear on deploying technology in austere environments, developing android applications, hardening the android operating system, geospatial and temporal visualization of SMS based reporting and information collection, crowd-sourced data collections, and ...

Modeling and simulation (M & S) technologies provide the capability for high-quality training in many areas of medicine while simultaneously reducing the costs and risks involved. However, M & S technologies require significant investment to realize their benefits, and it is crucial to have an appropriately designed system to best attain training objectives. The aim of this research is to develop ...

Phase I studies demonstrate that human adipose stem cells (ASCs) exhibit characteristics of chondrocytes when cultured in chondrogenic media (CM) and this is enhanced when they are first encapsulated in low viscosity, high mannuronate content alginate beads that are less than 200fYm in diameter containing 250 cells/bead. The microencapsulated cells express mRNAs for factors associated with chondr ...

The proposed Phase II program is designed to build upon the successes of the Phase I feasibility study and develop an advanced blood simulant for training of combat first responders in the use of modern hemostatic products. The blood simulant will exhibit a caking/clotting response in the presence of simulated hemostatic agents while accurately approximating the viscosity and color of human blood ...

The aim of this proposal is to develop an advanced blood simulant to replace current simulants used in combat medical training. A successful blood simulant will exhibit a caking/clotting response in the presence of simulated hemostatic agents while accur

As advances in battlefield care have led to increased survival, improved strategies for treating devastating, multi-tissue injuries are needed. Historical regenerative medicine strategies to restore function to damaged tissues have failed to fulfill the