Award Data

We have developed a device to control intracranial hemorrhage without a craniotomy.The device stops hemorrhage transcranially.This has been demonstrated in pig cadavers.We have developed a functional prototype and intend to improve and test the device on human cadavers and in vivo in pigs.By the end of the proposed work, we expect to be prepared to submit IDE paperwork with the FDA and engage inve ...

Current strategies for the treatment of osteochondral injuries are ineffective and are associated with significant side effects. Microfracture techniques have demonstrated limited efficacy over long periods of time and are less effective for larger osteochondral defects. Osteochondral autograft transplants require harvesting from a donor site, which can lead to donor site morbidity. Further, while ...

Traumatic brain injury is a common problem in both the military and civilian communities, but current treatment protocols are focused on managing symptoms and fail to prevent significant long-term repercussions. In the proposed program, Luna will demonstrate the feasibility of a liposome-based therapeutic delivery system capable of delivering hydrophilic and hydrophobic therapeutics to the traumat ...

Through previous grant awards from IES, researchers developed Graspable Math, a tablet-based intervention where middle and high school students create and manipulate complex expressions for basic operations as well as equations and equations systems and inequalities. In this project, the team will develop a prototype of Graspable Math Activities, an app with novel kinds of algebra practice and ass ...

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team.Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first true reduction performed by medical providers is on actual patients. This method of instruction prevents the trainee from developing the comfort a ...

Clinicians have recognized that the nature of diseases can be highly individual resulting in different patterns of onset and progression. In turn, the response of an individual to drugs is also unique and governed by a variety of factors. Pharmacokinetic models represent the movement of a drug through the body, and personalized pharmacokinetic models aim to capture the unique responses of specific ...

Medical simulation serves to bridge the gap between classroom presentation and live tissue training. Although simulation training can never completely replace live tissue training, it can enable earlier, more repetitive and more cost-effective training in proper technique, thereby accelerating development of the necessary cognitive and psychomotor skills. As combat medical training using human pat ...

Military Health Information Systems require trained and proficient personnel to support a wide range of system maintenance tasks to ensure the systems are secure and operational. However, the training requirements for these roles and the time required to perform them significantly detract from their primary roles as system users.QSI will develop and demonstrate an innovative software maintenance c ...

In this project, Parabon NanoLabs (PNL) will demonstrate the feasibility of extending its Essemblix(tm) Drug Development Platform, a combination of computer-aided design (CAD) software and DNA nano-fabrication technology, to produce Essemblix-V, a platform for creating artificial vaccines from a predefined set of"building block molecules"assembled on DNA origami. Given an epitope for a potential ...

Due to the possible transmission of blood-borne diseases, biting insects, mosquitoes, midges, and sand flies pose increasing danger to deployed military personnel and humans in locations around the globe. The SkySight Technologies approach to creating and demonstrating a tent trap to capture biting flies and mosquitoes that come to bite a human resting inside was to modify a standard tent with the ...