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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Image-Guided Transurethral HIFU for Genitourinary Therapy

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: 400

    DESCRIPTION provided by applicant Stress urinary incontinence SUI in women is an increase of pelvic floor compliance which results in decrease of urethral pressure typically through childbirth and presents as urine leakage during exertion SUI has significant impact on womenandapos s health including an association with increased levels of depression Curative options are limited to the in ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Development of biomarker of aging as predictor of AKI due to cardiac surgery

    SBC: HEALTHSPAN DIAGNOSTICS, LLC            Topic: N

    DESCRIPTION provided by applicant Acute kidney injury AKI is common expensive to treat and is associated with andgt mortality despite advances in supportive care Each year millions of patients undergo cardiovascular surgery medical imaging procedures or cytotoxic chemotherapy placing them at significant risk for developing AKI However while there is an immense clinical need to id ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Human induced pluripotent stem cell-derived beta-cells for drug and toxicity testing

    SBC: Regenerative Medical Solutions Inc            Topic: 200

    DESCRIPTION provided by applicant Diabetes represents a global health crisis In the United States alone approximately million people of the population suffer from diabetes resulting in direct medical costs of $ billion National Diabetes Statistics Report New medicines that can restore cell function in these patients thereby preventing or alleviating the debilitatin ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Improving the Host Response to Implantable Glucose Sensors via Nitric Oxide Release

    SBC: CLINICAL SENSORS, INC.            Topic: 200

    DESCRIPTION provided by applicant Diabetes mellitus is a metabolic disorder afflicting more than million Americans This disease manifests itself with abnormal blood glucose levels that lead to other significant health conditions including kidney failure nerve damage blindness heart attack and stroke For more than million diabetics using insulin to control hyperglycemia frequent moni ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Biguanides to Treat Type 2 Diabetes

    SBC: NOVATARG, INC.            Topic: 200

    DESCRIPTION provided by applicant The present Phase SBIR application builds on the previous Phase SBIR award to identify a markedly improved biguanide to replace metformin in the treatment of T D Over new biguanides were synthesized in the Phase work and analyzed for their ability to produce metformin like activity in cells and animal models but at a much lower effective concentratio ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Intrasurgical Optical Coherence Tomography

    SBC: BIOPTIGEN, INC.            Topic: N

    DESCRIPTION provided by applicant Each year over million ophthalmic surgeries are performed worldwide Indications for ophthalmic surgery include potentially blinding diseases such as cataracts diabetic retinopathy macular disease and retinal detachment Surgeons performing these delicate procedures are challenged by the translucent nature of tissues in the eye making it nearly impossi ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Integrated Systems for the Analysis of Circulating Multiple Myeloma Cells (CMMCs)

    SBC: BIOFLUIDICA, INC.            Topic: 102

    DESCRIPTION provided by applicant Multiple myeloma MM is a plasma cell malignancy and comprises about of malignant tumors and of all hematopoietic neoplasms According to the American Cancer Society in an estimated new cases were diagnosed in the U S with the estimated deaths being Monoclonal gammopathy of undetermined significance MGUS is associated with a p ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Novel and Kidney Selective AMPK Activators to Treat Polycystic Kidney Disease

    SBC: NOVATARG, INC.            Topic: 400

    DESCRIPTION provided by applicant Autosomal dominant polycystic kidney disease ADPKD is characterized by the presence of innumerous fluid filled cysts that progressively enlarge leading nephron loss and the progressive decline in renal function Aberrant proliferation of the cyst lining epithelial cells and the accumulation of fluid within the cysts du to Cl dependent fluid secretion are res ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Assay Development for Measuring Chemical Effects on the Epigenome in Stem Cells

    SBC: INTEGRATED LABORATORY SYSTEMS, LLC            Topic: 113

    DESCRIPTION provided by applicant This proposed project is in response to the need for more extensive toxicological evaluation of environmental chemicals and for better predictive models to assess associated risks of chemical exposure to humans There is also need for innovative methods for evaluating the effects of chemicals on pluripotent stem cells and the differentiation process Maintenan ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Nezavist a Novel Molecule for Treatment of Alcohol Use Disorder

    SBC: LOHOCLA RESEARCH CORPORATION            Topic: 150

    DESCRIPTION provided by applicant Alcohol Use Disorder affects of the U S population ages and older and costs society over $ billion per year in direct medical costs accidents and lost productivity Current pharmacotherapy is only modestly effective and has to be used in conjunction with psychosocial treatment Primary care physicians are ill equipped to provide the currently neces ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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