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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Nezavist a Novel Molecule for Treatment of Alcohol Use Disorder

    SBC: LOHOCLA RESEARCH CORPORATION            Topic: 150

    Abstract for Supplement ApplicationThe ultimate goal for our original project was to complete the proof-of-concept work, and the multitude of pharmacodynamic, pharmacokinetic, toxicokinetic, safety, and toxicology studies required by the FDA to apply for an IND. We are fully satisfied that we have generated a new chemical entity that acts at a novel binding site on the GABA-A receptor and acts in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Creating a predictive vascular system for early development

    SBC: HemoShear Therapeutics, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The frequent inability of in vitro assays and animal models to accurately predict human response to a new drug candidate results in costly drug development failures. HemoShear has developed a platform technology for biodiscovery and drug pharmacology screening that replicates human biological function in healthy and diseased organ systems by applying human-deri ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Development of next-generation Thrombelastographs

    SBC: CORAMED TECHNOLOGIES            Topic: NHLBI

    DESCRIPTION (provided by applicant): Coramed is commercializing next-generation point of care instruments, the TEG 6000 series, for monitoring patient hemostasis on demand. This project includes activities to take the technology from the prototype stage completed in Phase II to FDA-cleared and CLIA-waived commercial products. The planned devices introduce a completely new technology for monitoring ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  4. Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein-protein interaction

    SBC: ANAGIN            Topic: 103

    Abstract This application, “Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein- protein interaction,” addresses the critical need for more effective medications to treat chronic neuropathic pain affecting ~116 million people in the United States. Current pain medications such as NSAIDS, steroids, opiates and gabapentin analogs have documented and often severe sid ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Clinical Evaluation of a New Middle Ear Diagnostic to Support FDA Regulatory Clearance

    SBC: PHOTONICARE INC            Topic: NIDCD

    PROJECT SUMMARY IntroductionPhotoniCareIncis a medical device company nearing commercializing the ClearViewa handheldoptical imaging device for improved diagnosis of middle ear healthThe purpose of this proposaldeveloped in conjunction with the affiliated FDA review committeeis to perform pivotal clinical studies and use the collected data to establish objective data analysis algorithms for FDAkcl ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Real-time volumetric specimen imager for 3D intra-operative lumpectomy margin assessment

    SBC: CLARIX IMAGING CORP            Topic: 102

    Project Summary We propose to develop a novel volumetric specimen imagerVSIsystem for significantly reducing breast lumpectomy s reoperation rate and improving cosmetic outcomesAmong the annual performance of andgtlumpectomies in the USaboutof patients need reoperationswhen post surgery pathology examination revealspositive marginindicating incomplete tumor removal in initial surgeryCurrently phys ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Small Molecule Inhibitors of PCSK9-Phase II

    SBC: HINGEZ THERAPEUTICS INC            Topic: NHLBI

    Abstract Heart disease remains the leading cause of death in the USaccounting for nearlyof all deaths annuallyA high cholesterol level is a well known risk factor for heart diseaseAlthough blood cholesterollow density lipoproteinLDL Ccan be lowered using a number of marketed drugsonlyof patients taking these drugs are achieving the desired goalsFurthermorepatients with homozygous familial hypercho ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. IOBIO based, distributed genomic data access, management, visualization, and analysis

    SBC: FRAMESHIFT LABS INC            Topic: 172

    The precision medicine initiative coupled with advances in genomic research and diagnostics isleading to vast increases in the volume of genomic data being createdwith some estimates statingit will outstrip the storage requirements of YouTube byEnsuring all this data can becost effectively managedand that experts from the biomedicalinformatics and medical disciplinescan easily collaborate on analy ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Abstract The goal of this project is to develop a commercial analysis software platform that features the ability to detect and interpret copy number variantsCNVsand other types of structural variationsSVsfrom short read NextGen SequenceNGSdata to enable comprehensivewidely accessibleand economical genetic testingThis capability is key in clinical and research applicationsFor examplecurrently clin ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Epoch Telemetry System for Long-Term Monitoring of Biopotentials

    SBC: EPITEL, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Neonatal and childhood seizures can increase an individual's susceptibility for developing epilepsy later in life. Obtaining long-term continuous recordings of electrical events, such as the electroencephalogram (EEG), from animal models of neurological disease is a critical comp ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
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