Award Data

The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

Through previous grant awards from IES, researchers developed Graspable Math, a tablet-based intervention where middle and high school students create and manipulate complex expressions for basic operations as well as equations and equations systems and inequalities. In this project, the team will develop a prototype of Graspable Math Activities, an app with novel kinds of algebra practice and ass ...

Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

PROJECT SUMMARY Enzyme by DesignIncEbDis developing a safer version of L asparaginase that can be used routinely in the treatment of adult ALL patients whose hypersensitivity to todayandapos s bacterial L asparaginases deprives them from this efficacious therapyEbDandapos s L asparaginase is novel due to its mammalianguinea pigorigin and its lack of L glutaminase co activityThe need for better the ...

Combined in vivo and ex vivo three dimensionalDwhole brain imaging of non transgenic and transgenic animal models holds the promise of novel insights into neural network connectivity patternsWith regard to ex vivo light microscopic imaging ofD whole brain datasetsthe best approach is brain clearing followed by whole brain light sheet microscopyLSMbecause of its unique combination of speedD resolvi ...

Abstract Aboutleg and hip fractures each year are treated by implanting a stiff metal rod or intramedullaryIMnailthrough the center of the bone and fixing the ends of the nail to the bone with screwsBut placing the locking screws to fix the rod to the bone is difficultTo anchor the nail securelythe surgeon must accurately drill pilot holes through both the bone and locking holes in the nailwhile t ...

PROJECT SUMMARY Chemical risk assessment has been widely applied in chemical industry as a necessary step to get new commercial chemicals registeredand in governmental agencies as a critical procedure to evaluate the toxicity of chemicals in order to properly regulate them to protect human health and the environmentThe Lautenberg Chemical Safety Act further strengthens the importance of chemical r ...

SUMMARY ABSTRACT The goal of our predicate SBIR Phase I award is to develop genetically encoded fluorescent assays to detect cell stress in models of neurodegenerationTypically this degeneration is studied by counting dead cellsin animal or cellular models of the diseasewhich is an insensitive measurement of chronicslowcellular stressOur goal is to create genetically encodedfluorescent biosensors ...

PROJECT SUMMARY ABSTRACT Surefooted LLC is developing a novel type of physical therapy equipment with the potential to revolutionize fall preventionthe Surefooted TrainerTrainerinsenior citizens experience a fall each year and falls are the leading cause of death by an injury among those agedand olderCurrent treatments to prevent falls are inadequateThe Trainer consists of abyfoot platform with in ...

PROJECT SUMMARYOf themillion individuals worldwide with Alzheimer s disease and related dementiasADRDtotomillion individualssuffer dysphagia or swallowing problemsThe sequelae of dysphagia in this vulnerable population include malnutritiondehydrationand aspiration pneumoniaSince swallowing and breathing share a common anatomical pathwayprecise coordination is criticalIn normal individualsswallowin ...