Award Data

Combat vehicles must be completely decontaminated to eliminate threats to the health and safety of military personnel. This necessitates a portable, field deployable, self-contained, and automated washing system. Wastewater, mud, and debris from washing operations must be treated to destroy harmful contaminants. An enclosed washing system with specialized decontamination equipment will reduce the ...

The recent advances of modern high-throughput genomic technologies have resulted in a large number of fully sequenced microbial organisms. The construction of these comprehensive metabolic models serves many purposes including encapsulating all the data and allowing for in silco experiments to be performed that can drive experimental work and aid in strain development and optimization. The creatio ...

Rapid detection and identification of chemical warfare nerve agents (CWNAs) are critical to the screening and subsequent treatment of exposed warfighters. Inhibition of cholinesterase activity is insufficient as a marker of exposure to CWNAs, in that it can give misleading results and does not distinguish CWNAs from commonly employed pesticides. This proposal presents a revolutionary field-porta ...

This proposal aims at solving for a “Computer-Assisted Strain Construction and Development Engineering (CASCADE)” (SBIR CBD06-107). Our approach is to integrate BioSpice (a DOD product) and our statistical model developed by Quantum Intelligence together with publicly available data to develop a system for discovering the predictive relations between genomic fingerprints of an organism and it ...

The objective of the program is to demonstrate novel methods for achieving significant improvement in sensitivity of the active standoff chemical sensor operating in the 3-5 m and 10 m bands. Emphasis will be placed on photon detection improvement including reduction of background radiation and preamplifier noise reduction. Detector arrays will be studied for threat mapping applications. Tra ...

There is an urgent need for a rapid biological detection system that demonstrates the efficacy of decontamination products for inactivating Bacillus anthracis spores on environmental surfaces. To address the U.S. Army/CBD need for such a fieldable, rapid, NIST-certified, quantitative bio-indicator system, Physical Optics Corporation (POC) proposes to develop a new Spores Viability Detection (SVD) ...

Intelligent Optical Systems (IOS) proposes to develop a field-rugged, colorimetric indicating test paper that is capable of detecting multiple chemical warfare agents (CWAs), at low concentrations, in adverse environments. The proposed sensor array will detect threatening chemical agents and provide a visual readout after coming in contact with the agent, or agents. This array will overcome the st ...

Raman spectroscopy is a highly effective non-contact laser remote sensing method for detecting and identifying chemicals in every-day field environments. Raman spectroscopy is particularly suited for detecting trace surface contaminants that may indicate the presence of explosives, harmful chemical or biological agents. Contemporary systems, such as the vehicle mounted Joint Contaminated Surface D ...

Program tasks include analysis to improve wavelength diversity, high PRF discharges and catalysis in normal and isotopic pulsed CO2 laser mixtures, and high energy extraction in a single mode resonator. Analysis will be performed for pulse energy scaleup to the 1-5 J level at high PRF in support of the cloud search, track, and map functions. The impact of improved laser operation and enhanced da ...

This Small Business Innovation Research Phase I project will develop a non-animal based in-vitro assay for determining the efficacy of Botulinum (BoNT) neutralizing therapeutics; the dual nanopore assay (DNPA). New technologies are currently needed in order to facilitate the development and approval of BoNT vaccines and therapies, and align with the NIH and FDA"s guidance for reducing/replacing th ...