Award Data

DESCRIPTION (provided by applicant): Trace elements are well known to have critical roles in a wide variety of diseases, including cancer and neurodegenerative diseases such as Alzheimer's and Wilson's diseases. Due to their biological importance, there have been numerous studies performed with spectroscopy techniques such as laser ablation inductively coupled mass spectrometry (LA-ICP-M ...

DESCRIPTION (provided by applicant): ~ 22 million Americans have asthma, 6 million under 18. Annual cost of care is estimated at 19.7 billion, with 456,000 hospitalizations and 1.5 million ER visits. Inhaled corticosteroids effectively control symptoms and reduce morbidity, mortality and cost, but outpatient studies show that 28-56% of patients do not adhere to ICS regimens. A 1979 study of child ...

DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) or glioblastoma, is the most common and aggressive malignant primary brain tumor in humans. An effective treatment that increases patient survival would represent a significant advance inthe field, and provide a desperately needed new therapy for this deadly disease. EnduRx is focused on the development of new, targeted systems f ...

DESCRIPTION (provided by applicant): Most organic pharmaceutical chemical syntheses are done in organic solvents. Oxygen and/or water contaminants in organic solvents will destroy many organic reactants and organometallic reagents and catalysts. As such, the removal of oxygen and water are critical to successful organic synthesis. Unfortunately both oxygen and water are ubiquitous and significant ...

DESCRIPTION (provided by applicant): Compact Membrane Systems, Inc. is proposing a revision to grant 1 R43 GM084478-01A1 entitled Contaminate Removal for Laboratory Pharmaceutical Synthesis in response to notice NOT-OD-09-058, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications In this revision application, we are proposing to remove contaminants such as ...

DESCRIPTION: Enhanced Membrane System for Supplying Quality Drinking Water Contaminants in Drinking Water: While many of the traditional waterborne diseases (cholera, typhoid) are now uncommon in the developed world, the continue to be a major cause of disease in developing countries and waterborne disease kills more people worldwide than all forms of violence. Waterborne disease outbreaks contin ...

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In the proposed effort, we will leverage this extensive experience and capabilities to realize a frequency agile mmW radiometer that can cover the range of DC-110 GHz and can be scaled to DC-200 GHz under Phase II. Ours is a photonic system that multiplies and up-coverts a low-frequency reference signal onto an optical carrier (laser) using EO modulation, then uses the modulation sidebands to inj ...

DESCRIPTION (provided by applicant): Dry eye (DE) affects 25-30 million people in the U.S. alone and is responsible for 3.84 billion in direct annual health care costs. Evaporative dry eye (EDE) results from a lipid deficiency in tears causing the premature evaporation of tears. The problem to be solved is that current methods for accurately diagnosing EDE take time and are expensive. A fast, obj ...

DESCRIPTION: Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution liquid chromatographic (HPLC) separations for both small molecules and larger molecules such as proteins, peptides,glycopeptides, and glycans. Many HPLC separations of biomedical interest, such as proteomic or glycomic profiling, require hours or days for reso ...